Abstract
In neonatal intensive care units, there is a need for continuous monitoring of sick newborns with perinatal hypoxic ischemic brain injury (HIE). We assessed the utility of heart rate variability (HRV) in newborns with acute HIE undergoing simultaneous continuous EEG (cEEG) and ECG monitoring. HIE was classified using clinical criteria as well as visual grading of cEEG. Newborns were divided into two groups depending on the severity of the hypoxic injury and outcome. Various HRV parameters were compared between these groups, and significantly decreased HRV was found in neonates with severe HIE. As HRV is affected by many factors, it is difficult to attribute this difference solely to HIE. However, this study suggests that further investigation of HRV as a monitoring tool for acute neonatal hypoxic injury is warranted.
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Acknowledgments
This research is supported by Research Council KUL: GOA Ambiorics, GOA MaNet, CoE EF/05/006 Optimization in Engineering (OPTEC), IDO 05/010 EEG-fMRI, IDO 08/013 Autism, IOF-KP06/11 FunCopt; Flemish Government (FWO): PhD/postdoc grants, G.0302.07 (SVM), G.0341.07 (Data fusion), G.0427.10N (Integrated EEG-fMRI) research communities (ICCoS, ANMMM); IBBT; IWT: TBM070713-Accelero, TBM070706-IOTA3, TBM080658-MRI (EEG-fMRI), PhD Grants; Belgian Federal Science Policy Office: IUAP P6/04 (DYSCO, “Dynamical systems, control and optimization,” 2007–2011); ESA PRODEX No 90348 (sleep homeostasis); and EU: FAST (FP6-MC-RTN-035801), Neuromath (COST-BM0601).
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Matić, V. et al. (2013). Heart Rate Variability in Newborns with Hypoxic Brain Injury. In: Van Huffel, S., Naulaers, G., Caicedo, A., Bruley, D.F., Harrison, D.K. (eds) Oxygen Transport to Tissue XXXV. Advances in Experimental Medicine and Biology, vol 789. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7411-1_7
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DOI: https://doi.org/10.1007/978-1-4614-7411-1_7
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