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Adipose Tissue Macrophages in Obesity, Inflammation, and Cancer

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Obesity, Inflammation and Cancer

Part of the book series: Energy Balance and Cancer ((EBAC,volume 7))

Abstract

The chronic low-grade inflammation induced by obesity is a key connection between obesity and disease. It is now understood that the supporting stromal cells in adipose tissue contribute to this inflammatory response in significant ways. Of these, adipose tissue macrophages (ATMs) are major effectors of inflammation in hypertrophic adipose tissue. However, we now know that ATMs are diverse in their phenotypes and have functions that may contribute directly and indirectly to impact cancer risk. This review will summarize our current understanding of the phenotypic diversity in ATMs and how this is altered in obesity. The potential role that ATMs play in breast and ovarian cancer pathogenesis will also be discussed given the close association between adipose tissue and these cancer types.

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Acknowledgement

Support for this work was derived in part from NIH Grant DK090262 and DK092873.

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Authors and Affiliations

  1. Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, 4520B MSRB I, 1150 West Medical Center Drive, Ann Arbor, MI, 48109-0651, USA

    Carey Nien-Kai Lumeng M.D., Ph.D.

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Correspondence to Carey Nien-Kai Lumeng M.D., Ph.D. .

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  1. , Department of Medicine, Weill Cornell Medical College, 525 E. 68th St. Room F-206, New York, 10065, New York, USA

    Andrew J. Dannenberg

  2. School of Medicine, Center for Science, Health & Society, Case Western Reserve University, Euclid Ave. 10900, Cleveland, 44106, Ohio, USA

    Nathan A. Berger

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Lumeng, C.NK. (2013). Adipose Tissue Macrophages in Obesity, Inflammation, and Cancer. In: Dannenberg, A., Berger, N. (eds) Obesity, Inflammation and Cancer. Energy Balance and Cancer, vol 7. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6819-6_4

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