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Anti-inflammatory Effects of Exercise

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Obesity, Inflammation and Cancer

Part of the book series: Energy Balance and Cancer ((EBAC,volume 7))

Abstract

Chronic low-level inflammation is associated with obesity and increased incidence of cancer and chronic disease states. Regular exercise reduces the risk of some cancers as well as chronic metabolic and cardiorespiratory diseases, in part because exercise exerts anti-inflammatory effects. The anti-inflammatory effects of regular exercise may be mediated via both a reduction in visceral fat mass (with a subsequent decreased release of adipokines) and the induction of an anti-inflammatory environment with each bout of exercise via the release of IL-6 from working skeletal muscle, reduced expression of TLRs on monocytes/macrophages, inhibition of monocyte/macrophage infiltration into adipose tissue, phenotypic switching of macrophages within adipose tissue, a reduction in the circulating numbers of pro-inflammatory monocytes and an increase in the circulating numbers of regulatory T cells.

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  1. School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, Leicestershire, LE11 3TU, UK

    Michael Gleeson Ph.D.

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  1. Michael Gleeson Ph.D.
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Correspondence to Michael Gleeson Ph.D. .

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  1. , Department of Medicine, Weill Cornell Medical College, 525 E. 68th St. Room F-206, New York, 10065, New York, USA

    Andrew J. Dannenberg

  2. School of Medicine, Center for Science, Health & Society, Case Western Reserve University, Euclid Ave. 10900, Cleveland, 44106, Ohio, USA

    Nathan A. Berger

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Gleeson, M. (2013). Anti-inflammatory Effects of Exercise. In: Dannenberg, A., Berger, N. (eds) Obesity, Inflammation and Cancer. Energy Balance and Cancer, vol 7. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6819-6_16

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