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Heart Mitochondria: Receivers and Transmitters of Signals

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Mitochondria and Their Role in Cardiovascular Disease

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Abstract

Besides their central bioenergetic role in supplying ATP, heart mitochondria play an essential role in the regulatory and signaling events that occur in response to physiological stresses, including but not limited to heart failure (HF), myocardial ischemia and reperfusion injury (IRI), hypoxia, oxidative stress (OS), and hormonal and cytokine stimuli. Research on both intact cardiac and skeletal muscle tissue and cultured cardiomyocytes has just begun to probe the nature and the extent of mitochondrial involvement in interorganelle communication, hypertrophic growth, and cell death. In this chapter we will discuss mitochondria participation, at the molecular and biochemical levels, in the multiple and interrelated signaling pathways, gauging the effect that mitochondria have as a receiver, integrator, and transmitter of signals on cardiac phenotype.

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    José Marín-García M.D.

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Marín-García, J. (2013). Heart Mitochondria: Receivers and Transmitters of Signals. In: Mitochondria and Their Role in Cardiovascular Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-4599-9_8

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