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Evolutionary Principles in Viral Epitopes

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Mathematical Methods and Models in Biomedicine

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Abstract

The infection of a cell by a virus elicits a Cytotoxic T Lymphocyte (CTL) response to viral peptides presented by the Major Histocompatibility Complex class I molecules [6, 20]. Such a CTL response plays a critical role in the host’s anti-viral immune response [39]. This role is suggested by studies indicating a drop of viral loads and the relief of the acute infection symptoms following the emergence of virus-specific CTLs [8], as well as by data from CTL depleted animal models [33, 41]. The CTL response is also associated with a rapid selection of viral CTL escape variants [23, 34]. In the last few years we have applied an immunomic methodology combining genomic data and multiple bioinformatic tools to study the anti-viral CTL response [5, 19, 28, 35, 38, 55–57] and found that viruses selectively mutate proteins inducing the highest danger to their survival. We here summarize these results, and propose some general conclusions regarding the selective forces affecting viruses and their human host.

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Authors and Affiliations

  1. The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, 52900, Israel

    Yaakov Maman

  2. Department of Mathematics and Gonda Brain Research Center, Bar-Ilan University, Ramat Gan, 52900, Israel

    Alexandra Agranovich, Tal Vider Shalit & Yoram Louzoun

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  1. Yaakov Maman
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  2. Alexandra Agranovich
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  3. Tal Vider Shalit
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  4. Yoram Louzoun
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Correspondence to Yoram Louzoun .

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Editors and Affiliations

  1. , Mathematics and Statistics, Southern Illinois University Edwardsvill, Edwardsville, 62026, Illinois, USA

    Urszula Ledzewicz

  2. , Electrical and Systems Engineering, Washington University, Brookings Drive 1, Saint Louis, 63130, Missouri, USA

    Heinz Schättler

  3. Mathematical Biosciences Institute, Ohio State University, W. 18th Avenue 231, Columbus, 43210-1292, Ohio, USA

    Avner Friedman

  4. Tel Aviv University, Ramat Aviv, Tel Aviv, 69978, Israel

    Eugene Kashdan

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Maman, Y., Agranovich, A., Shalit, T.V., Louzoun, Y. (2013). Evolutionary Principles in Viral Epitopes. In: Ledzewicz, U., Schättler, H., Friedman, A., Kashdan, E. (eds) Mathematical Methods and Models in Biomedicine. Lecture Notes on Mathematical Modelling in the Life Sciences. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4178-6_3

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