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Etiology and Epidemiology of CLL

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Neoplastic Diseases of the Blood

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Abstract

Chronic lymphocytic leukemia (CLL) is an indolent disease resulting from an accumulation of CD5-positive neoplastic B-cells characterized by a low rate of proliferation. Despite CLL accounting for approximately 25 % of all leukemia and being the most common form of lymphoid malignancy in Western countries [1], our understanding of its biological basis is only starting to be unraveled.

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Authors and Affiliations

  1. Department of Cancer Genetics, The Institute of Cancer Research, Belmont, Surrey, SM2 5NG, UK

    Dalemari Crowther-Swanepoel B.Sc. (Hons) Genetics (Ph.D) & Richard S. Houlston M.D., Ph.D., F.R.C.Path., F.R.C.Pi

  2. Department of Hemato-oncology, The Institute of Cancer Research and Royal Marsden Hospital NHS Trust, Belmont, Surrey, SM2 5NG, UK

    Daniel Catovsky D.Sc., F.R.C.P., F.R.C.Path., F.Med.Sci.

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  1. Dalemari Crowther-Swanepoel B.Sc. (Hons) Genetics (Ph.D)
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  2. Daniel Catovsky D.Sc., F.R.C.P., F.R.C.Path., F.Med.Sci.
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  3. Richard S. Houlston M.D., Ph.D., F.R.C.Path., F.R.C.Pi
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Corresponding author

Correspondence to Richard S. Houlston M.D., Ph.D., F.R.C.Path., F.R.C.Pi .

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Editors and Affiliations

  1. Beth Israel Hospital, Cancer Center, St. Lukes-Roosevelt Hospital Center, 10th Avenue 1000, New York, 10019, New York, USA

    Peter H. Wiernik

  2. , Department of Hematology, Imperial College of London, Du Cane Road 150, London, W12 0NN, United Kingdom

    John M. Goldman

  3. Continuum Cancer Centers, Department of Medicine, St. Luke's-Roosevelt Hospital Center, 10th Avenue 1000, New York, 10019, New York, USA

    Janice P. Dutcher

  4. , Division of Hematology, Mayo Clinic, First Street SW. 200, Rochester, 55905, Minnesota, USA

    Robert A. Kyle

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Crowther-Swanepoel, D., Catovsky, D., Houlston, R.S. (2013). Etiology and Epidemiology of CLL. In: Wiernik, P., Goldman, J., Dutcher, J., Kyle, R. (eds) Neoplastic Diseases of the Blood. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3764-2_6

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  • DOI: https://doi.org/10.1007/978-1-4614-3764-2_6

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