Skip to main content

Interstitial Radiation Therapy in Cancer of the Oropharynx and Oral Cavity

  • Chapter
  • First Online:
Head and Neck Cancer

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 279.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

Notes

  1. 1.

    Unfortunately, not systemically scored/reported in charts.

References

  1. Overgaard J. Chemoradiotherapy of head and neck cancer – can the bumble bee fly? Radiother Oncol. 2009;92:1–3.

    Article  PubMed  Google Scholar 

  2. Levendag PC, Teguh DN, Voet P, Van der Est H, Noever I, de Kruijf WJ, et al. Dysphagia disorders in patients with cancer of the oropharynx are significantly affected by the radiation therapy dose to the superior and middle constrictor muscle: a dose-effect relationship. Radiother Oncol. 2007;85:64–73.

    Article  PubMed  Google Scholar 

  3. Bourhis J, Overgaard J, Audry H, Ang KK, Saunders M, Bernier J, et al. Hyperfractionated or accelerated radiotherapy in head and neck cancer: a meta-analysis. Lancet. 2006;368:843–54.

    Article  PubMed  Google Scholar 

  4. Grimard L, Esche B, Lamothe A, Spaans JN. Interstitial brachytherapy in the management of persistent head and neck disease after definitive external beam radiation therapy. Brachytherapy. 2009;8:284–9.

    Article  PubMed  Google Scholar 

  5. Glatzel M, Buntzel J, Schroder D, Kuttner K, Frohlich D. High-dose-rate brachytherapy in the treatment of recurrent and residual head and neck cancer. Laryngoscope. 2002;112:1366–71.

    Article  PubMed  Google Scholar 

  6. Grimard L, Esche B, Lamothe A, Cygler J, Spaans J. Interstitial low-dose-rate brachytherapy in the treatment of recurrent head and neck malignancies. Head Neck. 2006;28:888–95.

    Article  PubMed  Google Scholar 

  7. Narayana A, Cohen GN, Zaider M, Chan K, Lee N, Wong RJ, et al. High-dose-rate interstitial brachytherapy in recurrent and previously irradiated head and neck cancers – preliminary results. Brachytherapy. 2007;6:157–63.

    Article  PubMed  Google Scholar 

  8. Crook J, Mazeron JJ, Marinello G. Combined external and interstitial implantation for T1 and T2 epidermoid carcinoma of base of tongue: the Creteil experience. Int J Radiat Oncol Biol Phys. 1988;15:105–14.

    Article  PubMed  CAS  Google Scholar 

  9. Esche BA, Haie CM, Gerbaulet AP, Eschwege F, Richard JM, Chassagne D. Interstitial and external radiotherapy in carcinoma of the soft palate and uvula. Int J Radiat Oncol Biol Phys. 1988;15:619–25.

    Article  PubMed  CAS  Google Scholar 

  10. Foote RL, Parsons JT, Mendenhall WM, Million RR, Cassisi NJ, Stringer SP. Is interstitial implantation essential for successful radiotherapeutic treatment of base of tongue carcinoma? Int J Radiat Oncol Biol Phys. 1990;18:1293–8.

    Article  PubMed  CAS  Google Scholar 

  11. Gerbaulet A, Poetter R, Mazeron JJ. The GEC ESTRO handbook of brachytherapy. Brussels, Belgium: ESTRO; 2002. ISBN 90-804532-6.

    Google Scholar 

  12. Goffinet DR, Fee Jr WE, Wells J, Austin-Seymour M, Clarke D, Mariscal JM, et al. 192Ir pharyngoepiglottic fold interstitial implants. The key to successful treatment of base tongue carcinoma by radiation therapy. Cancer. 1985;55:941–8.

    Article  PubMed  CAS  Google Scholar 

  13. Harrison LB, Lee HJ, Pfister DG, Kraus DH, White C, Raben A, et al. Long term results of primary radiotherapy with/without neck dissection for squamous cell cancer of the base of tongue. Head Neck. 1998;20:668–73.

    Article  PubMed  CAS  Google Scholar 

  14. Horwitz EM, Frazier AJ, Martinez AA, Keidan RD, Clarke DH, Lacerna MD, et al. Excellent functional outcome in patients with squamous cell carcinoma of the base of tongue treated with external irradiation and interstitial iodine 125 boost. Cancer. 1996;78:948–57.

    Article  PubMed  CAS  Google Scholar 

  15. Housset M, Baillet F, Dessard-Diana B, Martin D, Miglianico L. A retrospective study of three treatment techniques for T1-T2 base of tongue lesions: surgery plus postoperative radiation, external radiation plus interstitial implantation and external radiation alone. Int J Radiat Oncol Biol Phys. 1987;13:511–6.

    Article  PubMed  CAS  Google Scholar 

  16. Levendag P, Nijdam W, Noever I, Schmitz P, van de Pol M, Sipkema D, et al. Brachytherapy versus surgery in carcinoma of tonsillar fossa and/or soft palate: late adverse sequelae and performance status: can we be more selective and obtain better tissue sparing? Int J Radiat Oncol Biol Phys. 2004;59:713–24.

    Article  PubMed  Google Scholar 

  17. Levendag PC, Schmitz PI, Jansen PP, Senan S, Eijkenboom WM, Sipkema D, et al. Fractionated high-dose-rate and pulsed-dose-rate brachytherapy: first clinical experience in squamous cell carcinoma of the tonsillar fossa and soft palate. Int J Radiat Oncol Biol Phys. 1997;38:497–506.

    Article  PubMed  CAS  Google Scholar 

  18. Mazeron JJ, Marinello G, Crook J, Marin L, Mahot P, Raynal M, et al. Definitive radiation treatment for early stage carcinoma of the soft palate and uvula: the indications for iridium 192 implantation. Int J Radiat Oncol Biol Phys. 1987;13:1829–37.

    Article  PubMed  CAS  Google Scholar 

  19. Mazeron JJ, Crook JM, Benck V, Marinello G, Martin M, Raynal M, et al. Iridium 192 implantation of T1 and T2 carcinomas of the mobile tongue. Int J Radiat Oncol Biol Phys. 1990;19:1369–76.

    Article  PubMed  CAS  Google Scholar 

  20. Pernot M, Hoffstetter S, Peiffert D, Aletti P, Lapeyre M, Marchal C, et al. Role of interstitial brachytherapy in oral and oropharyngeal carcinoma: reflection of a series of 1344 patients treated at the time of initial presentation. Otolaryngol Head Neck Surg. 1996;115:519–26.

    Article  PubMed  CAS  Google Scholar 

  21. van de Pol M, Levendag PC, de Bree RR, Franssen JH, Smeele LE, Nijdam WM, et al. Radical radiotherapy compared with surgery for advanced squamous cell carcinoma of the base of tongue. Brachytherapy. 2004;3:78–86.

    Article  PubMed  Google Scholar 

  22. Vikram B, Hilaris BS. A non-looping afterloading technique for interstitial implants of the base of the tongue. Int J Radiat Oncol Biol Phys. 1981;7:419–22.

    Article  PubMed  CAS  Google Scholar 

  23. Vikram B, Strong E, Shah J, Spiro R, Gerold F, Sessions R, et al. A non-looping afterloading technique for base of tongue implants: results in the first 20 patients. Int J Radiat Oncol Biol Phys. 1985;11:1853–5.

    Article  PubMed  CAS  Google Scholar 

  24. Halperin EC, Perez CA, Brady LW. Perez and Brady’s principles and practice of radiation oncology. Philadelphia, PA: Lippincott Williams & Wilkins; 2009.

    Google Scholar 

  25. Pignon JP, Bourhis J, Domenge C, Designe L. Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data. MACH-NC Collaborative Group. Meta-analysis of chemotherapy on head and neck cancer. Lancet. 2000;355:949–55.

    PubMed  CAS  Google Scholar 

  26. Lefebvre JL, Coche-Dequeant B, Buisset E, Mirabel X, Van JT, Prevost B. Management of early oral cavity cancer. Experience of Centre Oscar Lambret. Eur J Cancer B Oral Oncol. 1994;30B:216–20.

    Article  PubMed  CAS  Google Scholar 

  27. Lee IJ, Koom WS, Lee CG, Kim YB, Yoo SW, Keum KC, et al. Risk factors and dose-effect relationship for mandibular osteoradionecrosis in oral and oropharyngeal cancer patients. Int J Radiat Oncol Biol Phys. 2009;75(4):1084–91.

    Article  PubMed  Google Scholar 

  28. Greene FL, Page DL, Fleming ID, et al. AJCC cancer staging manual. 6th ed. New York: Springer; 2006.

    Book  Google Scholar 

  29. Levendag PC, Al-Mamgani A, Teguh DN. Contouring in head & neck cancer. München: Elsevier Professional Education; 2009. p. 17–25.

    Google Scholar 

  30. Wendt CD, Peters LJ, Delclos L, Ang KK, Morrison WH, Maor MH, et al. Primary radiotherapy in the treatment of stage I and II oral tongue cancers: importance of the proportion of therapy delivered with interstitial therapy. Int J Radiat Oncol Biol Phys. 1990;18:1287–92.

    Article  PubMed  CAS  Google Scholar 

  31. Wadsley JC, Patel M, Tomlins CD, Gildersleve JQ. Iridium-192 implantation for T1 and T2a carcinoma of the tongue and floor of mouth: retrospective study of the results of treatment at the Royal Berkshire Hospital. Br J Radiol. 2003;76:414–7.

    Article  PubMed  CAS  Google Scholar 

  32. Pernot M, Malissard L, Hoffstetter S, Luporsi E, Peiffert D, Aletti P, et al. The study of tumoral, radiobiological, and general health factors that influence results and complications in a series of 448 oral tongue carcinomas treated exclusively by irradiation. Int J Radiat Oncol Biol Phys. 1994;29:673–9.

    Article  PubMed  CAS  Google Scholar 

  33. Mendenhall WM, Parsons JT, Stringer SP, Cassisi NJ, Million RR. T2 oral tongue carcinoma treated with radiotherapy: analysis of local control and complications. Radiother Oncol. 1989;16:275–81.

    Article  PubMed  CAS  Google Scholar 

  34. Inoue T, Inoue T, Yoshida K, Yoshioka Y, Shimamoto S, Tanaka E, et al. Phase III trial of high- vs. low-dose-rate interstitial radiotherapy for early mobile tongue cancer. Int J Radiat Oncol Biol Phys. 2001;51:171–5.

    PubMed  CAS  Google Scholar 

  35. Decroix Y, Ghossein NA. Experience of the Curie Institute in treatment of cancer of the mobile tongue: I. Treatment policies and result. Cancer. 1981;47:496–502.

    Article  PubMed  CAS  Google Scholar 

  36. Benk V, Mazeron JJ, Grimard L, Crook J, Haddad E, Piedbois P, et al. Comparison of curietherapy versus external irradiation combined with curietherapy in stage II squamous cell carcinomas of the mobile tongue. Radiother Oncol. 1990;18:339–47.

    Article  PubMed  CAS  Google Scholar 

  37. Baillet F, Delouche G, Bachelot F. Epithelioma of the floor of mouth: multicentre retrospective study of 908 cases. J Eur Radiother. 1982;3:147–52.

    Google Scholar 

  38. Piccirillo JF, Vlahiotis A. Comorbidity in patients with cancer of the head and neck: prevalence and impact on treatment and prognosis. Curr Oncol Rep. 2006;8:123–9.

    Article  PubMed  Google Scholar 

  39. Mazeron JJ, Crook J, Martin M, Peynegre R, Pierquin B. Iridium 192 implantation of squamous cell carcinomas of the oropharynx. Am J Otolaryngol. 1989;10:317–21.

    Article  PubMed  CAS  Google Scholar 

  40. Teguh DN, Levendag PC, Noever I, Voet P, Van der Est H, van Rooij P, et al. Early hyperbaric oxygen therapy for reducing radiotherapy side effects: early results of a randomized trial in oropharyngeal and nasopharyngeal cancer. Int J Radiat Oncol Biol Phys. 2009;75:711–6.

    Article  PubMed  Google Scholar 

  41. Gibbs IC, Le QT, Shah RD, Terris DJ, Fee WE, Goffinet DR. Long-term outcomes after external beam irradiation and brachytherapy boost for base-of-tongue cancers. Int J Radiat Oncol Biol Phys. 2003;57:489–94.

    Article  PubMed  Google Scholar 

  42. Anderson LL. A “natural” volume-dose histogram for brachytherapy. Med Phys. 1986;13:898–903.

    Article  PubMed  CAS  Google Scholar 

  43. Das RK. ICRU 58 (dose and volume specification for reporting interstitial therapy), by International Commission on Radiation Units and Measurements. Med Phys. 1998;25(7):1225–2008.

    Article  Google Scholar 

  44. Kolkman-Deurloo IK, Visser AG, Niel CG, Driver N, Levendag PC. Optimization of interstitial volume implants. Radiother Oncol. 1994;31:229–39.

    Article  PubMed  CAS  Google Scholar 

  45. Saw CB, Suntharalingam N. Quantitative assessment of interstitial implants. Int J Radiat Oncol Biol Phys. 1991;20:135–9.

    Article  PubMed  CAS  Google Scholar 

  46. Thomadsen BR, Houdek PV, van der Laarse R, Edmunson G, Kolkman-Deurloo IKK, Visser AG. Treatment planning and optimization. In: Nag S, editor. HDR brachytherapy: a textbook. Armonk, NY: Futura; 1994. p. 79–145.

    Google Scholar 

  47. Harrison LB, Zelefsky MJ, Pfister DG, Carper E, Raben A, Kraus DH, et al. Detailed quality of life assessment in patients treated with primary radiotherapy for squamous cell cancer of the base of the tongue. Head Neck. 1997;19:169–75.

    Article  PubMed  CAS  Google Scholar 

  48. Babin E, Sigston E, Hitier M, Dehesdin D, Marie JP, Choussy O. Quality of life in head and neck cancers patients: predictive factors, functional and psychosocial outcome. Eur Arch Otorhinolaryngol. 2008;265:265–70.

    Article  PubMed  CAS  Google Scholar 

  49. Pourel N, Peiffert D, Lartigau E, Desandes E, Luporsi E, Conroy T. Quality of life in long-term survivors of oropharynx carcinoma. Int J Radiat Oncol Biol Phys. 2002;54:742–51.

    Article  PubMed  Google Scholar 

  50. Hammerlid E, Mercke C, Sullivan M, Westin T. A prospective quality of life study of patients with oral or pharyngeal carcinoma treated with external beam irradiation with or without brachytherapy. Oral Oncol. 1997;33:189–96.

    Article  PubMed  CAS  Google Scholar 

  51. Caudell JJ, Schaner PE, Meredith RF, Locher JL, Nabell LM, Carroll WR, et al. Factors associated with long-term dysphagia after definitive radiotherapy for locally advanced head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2009;73:410–5.

    Article  PubMed  Google Scholar 

  52. Dornfeld K, Simmons JR, Karnell L, Karnell M, Funk G, Yao M, et al. Radiation doses to structures within and adjacent to the larynx are correlated with long-term diet- and speech-related quality of life. Int J Radiat Oncol Biol Phys. 2007;68:750–7.

    Article  PubMed  Google Scholar 

  53. Feng FY, Kim HM, Lyden TH, Haxer MJ, Feng M, Worden FP, et al. Intensity-modulated radiotherapy of head and neck cancer aiming to reduce dysphagia: early dose-effect relationships for the swallowing structures. Int J Radiat Oncol Biol Phys. 2007;8:1289.

    Article  Google Scholar 

  54. Jensen K, Lambertsen K, Grau C. Late swallowing dysfunction and dysphagia after radiotherapy for pharynx cancer: frequency, intensity and correlation with dose and volume parameters. Radiother Oncol. 2007;85:74–82.

    Article  PubMed  Google Scholar 

  55. Mangar S, Slevin N, Mais K, Sykes A. Evaluating predictive factors for determining enteral nutrition in patients receiving radical radiotherapy for head and neck cancer: a retrospective review. Radiother Oncol. 2006;78:152–8.

    Article  PubMed  Google Scholar 

  56. Poulsen MG, Riddle B, Keller J, Porceddu SV, Tripcony L. Predictors of acute grade 4 swallowing toxicity in patients with stages III and IV squamous carcinoma of the head and neck treated with radiotherapy alone. Radiother Oncol. 2008;87:253–9.

    Article  PubMed  Google Scholar 

  57. Teguh DN, Levendag PC, Sewnaik A, Hakkesteegt MM, Noever I, Voet P. Results of fiberoptic endoscopic evaluation of swallowing vs. radiation dose in the swallowing muscles after radiotherapy of cancer in the oropharynx. Radiother Oncol. 2008;89:57–63.

    Article  PubMed  Google Scholar 

  58. Teguh DN, Levendag PC, Noever I, van Rooij P, Voet P, Van der Est H. Treatment techniques and site considerations regarding dysphagia-related quality of life in cancer of the oropharynx and nasopharynx. Int J Radiat Oncol Biol Phys. 2008;72:1119–27.

    Article  PubMed  Google Scholar 

  59. Bjordal K, de Graeff A, Fayers PM, Hammerlid E, van Pottelsberghe C, Curran D, et al. A 12 country field study of the EORTC QLQ-C30 (version 3.0) and the head and neck cancer specific module (EORTC QLQ-H&N35) in head and neck patients. EORTC Quality of Life Group. Eur J Cancer. 2000;36:1796–807.

    Article  PubMed  CAS  Google Scholar 

  60. List MA, D’Antonio LL, Cella DF, Siston A, Mumby P, Haraf D, et al. The performance status scale for head and neck cancer patients and the functional assessment of cancer therapy head and neck scale – A study of utility and validity. Cancer. 1996;77:2294–301.

    Article  PubMed  CAS  Google Scholar 

  61. Chen AY, Frankowski R, Bishop-Leone J, Hebert T, Leyk S, Lewin J, et al. The development and validation of a dysphagia-specific quality-of-life questionnaire for patients with head and neck cancer: the M. D. Anderson dysphagia inventory. Arch Otolaryngol Head Neck Surg. 2001;127:870–6.

    PubMed  CAS  Google Scholar 

  62. Teguh DN, Levendag PC, Kolkman-Deurloo IK, van Rooij P, Schmitz PI. Quality of life of oropharyngeal cancer patients treated with brachytherapy. Curr Oncol Rep. 2009;11:143–50.

    Article  PubMed  Google Scholar 

  63. Vasquez Osorio EM, Hoogeman MS, Bondar L, Levendag PC, Heijmen BJ. A novel flexible framework with automatic feature correspondence optimization for nonrigid registration in radiotherapy. Med Phys. 2009;36:2848–59.

    Article  PubMed  Google Scholar 

  64. Han X, Hoogeman MS, Levendag PC, Hibbard LS, Teguh DN, Voet P, et al. Atlas-based auto-segmentation of head and neck CT images. Med Image Comput Comput Assist Interv. 2008;11:434–41.

    PubMed  Google Scholar 

  65. Barrett WL, Gluckman JL, Wilson KM, Gleich LL. A comparison of treatments of squamous cell carcinoma of the base of tongue: surgical resection combined with external radiation therapy, external radiation therapy alone, and external radiation therapy combined with interstitial radiation. Brachytherapy. 2004;3:240–5.

    Article  PubMed  Google Scholar 

  66. Brunin F, Mosseri V, Jaulerry C, Point D, Cosset JM, Rodriguez J. Cancer of the base of the tongue: past and future. Head Neck. 1999;21:751–9.

    Google Scholar 

  67. Chu A, Fletcher GH. Incidence and causes of failures to control by irradiation the primary lesions in squamous cell carcinomas of the anterior two-thirds of the tongue and floor of mouth. Am J Roentgenol Radium Ther Nucl Med. 1973;117:502–8.

    Google Scholar 

  68. Hoffstetter S, Malissard L, Pernot M, Luporsi E, Peiffert D, Lapeyre M. Retrospective study of 136 cases of epidermoid carcinoma of the base of the tongue treated at the Alexis Vautrin Centre 1978–1992. Bull Cancer Radiother. 1996;83:90–6.

    Google Scholar 

  69. Karakoyun-Celik O, Norris CM, Jr., Tishler R, et al. Definitive radiotherapy with interstitial implant boost for squamous cell carcinoma of the tongue base. Head Neck. 2005;27:353–61.

    Google Scholar 

  70. Lusinchi A, Eskandari J, Son Y, et al. External irradiation plus curietherapy boost in 108 base of tongue carcinomas. Int J Radiat Oncol Biol Phys. 1989;17:1191–7.

    Google Scholar 

  71. Mazeron JJ, Belkacemi Y, Simon JM, et al. Place of Iridium 192 implantation in definitive irradiation of faucial arch squamous cell carcinomas. Int J Radiat Oncol Biol Phys. 1993;27:251–7.

    Google Scholar 

  72. Peiffert D, Pernot M, Malissard L, et al. Salvage irradiation by brachytherapy of velotonsillar squamous cell carcinoma in a previously irradiated field: results in 73 cases. Int J Radiat Oncol Biol Phys. 1994;29:681–6.

    Google Scholar 

  73. Pernot M, Malissard L, Taghian A, et al. Velotonsillar squamous cell carcinoma: 277 cases treated by combined external irradiation and brachytherapy–results according to extension, localization, and dose rate. Int J Radiat Oncol Biol Phys. 1992;23:715–23.

    Google Scholar 

  74. Puthawala AA, Syed AM, Eads DL, Neblett D, Gillin L, Gates TC. Limited external irradiation and interstitial 192 iridium implant in the treatment of squamous cell carcinoma of the tonsillar region. Int J Radiat Oncol Biol Phys. 1985;11:1595–602.

    Google Scholar 

  75. Puthawala AA, Syed AM, Eads DL, Gillin L, Gates TC. Limited external beam and interstitial 192 iridium irradiation in the treatment of carcinoma of the base of the tongue: a ten year experience. Int J Radiat Oncol Biol Phys. 1988;14:839–48.

    Google Scholar 

  76. Takacsi-Nagy Z, Polgar C, Oberna F, et al. Interstitial high-dose-rate brachytherapy in the treatment of base of tongue carcinoma. Strahlenther Onkol. 2004;180:768–75.

    Google Scholar 

  77. Gibbs IC, Le QT, Shah RD, Terris DJ, Fee WE, and Goffinet DR. Long-term outcomes after external beam irradiation and brachytherapy boost for base-of-tongue cancers. Int J Radiat Oncol Biol Phys. 2003;57:489–494.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Peter C. Levendag .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Levendag, P.C., Teguh, D.N., Schmitz, P.I.M. (2011). Interstitial Radiation Therapy in Cancer of the Oropharynx and Oral Cavity. In: Bernier, J. (eds) Head and Neck Cancer. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9464-6_42

Download citation

  • DOI: https://doi.org/10.1007/978-1-4419-9464-6_42

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4419-9463-9

  • Online ISBN: 978-1-4419-9464-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics