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Tissue Microarray Applications in Drug Discovery for Pancreatic Cancer

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Drug Discovery in Pancreatic Cancer

Abstract

The rising incidence of pancreatic cancer combined with limited responses to chemotherapy highlights the need for improved molecular characterization in this highly lethal cancer. The discovery and validation of novel biomarkers are urgently needed to improve early detection and thereby improve survival outcomes. The introduction and widespread application of tissue microarrays (TMAs) over the past decade provide a valuable tool for validation of abundance and cellular localization of expressed proteins and RNA transcript levels contextually within the complex tissue morphology of pancreatic cancer. The TMA format offers a standardized platform to optimize and validate newly identified biomarkers and drug targets in pancreatic cancer research to patient tumor samples to provide critical links in advancing cancer research findings to the clinical setting.

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Author information

Authors and Affiliations

  1. Integrated Cancer Genomics Division, Translational Genomics Research Institute, 445 N. Fifth Street, Phoenix, AZ, 85004, USA

    Galen Hostetter

Authors
  1. Aprill Watanabe
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  2. Galen Hostetter
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Correspondence to Galen Hostetter .

Editor information

Editors and Affiliations

  1. Institute, Translational Genomics Research, 445 N. Fifth Street, Phoenix, 85004, U.S.A.

    Haiyong Han

  2. Feinberg School of Medicine, Northwestern University, Chicago, 60611, U.S.A.

    Paul Grippo

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Watanabe, A., Hostetter, G. (2010). Tissue Microarray Applications in Drug Discovery for Pancreatic Cancer. In: Han, H., Grippo, P. (eds) Drug Discovery in Pancreatic Cancer. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1160-5_11

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