Abstract
The supramolecular composites containing fullerenes C60 immobilized at nanosilica were used for the design of the molecular systems that can be an effective agent in cancer photodynamic therapy (PDT). In particular, it was shown that photoexcited fullerene C60-containing composites decrease viability of transformed cells, intensify the process of lipid peroxidation (LPO) in cell membranes and accumulation of low-molecular weight DNA fragments, and also decrease the activity of electron-transport chain of mitochondria.
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Prylutska, S.V. et al. (2008). Effects of Photoexcited Fullerene C60-Composites in Normal and Transformed Cells. In: Cataldo, F., Da Ros, T. (eds) Medicinal Chemistry and Pharmacological Potential of Fullerenes and Carbon Nanotubes. Carbon Materials: Chemistry and Physics, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6845-4_6
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DOI: https://doi.org/10.1007/978-1-4020-6845-4_6
Publisher Name: Springer, Dordrecht
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