Abstract
Among many pathological processes, angiogenesis, the formation of new blood vessels from pre-existing blood vessels, has received much attention during the last few decades in the field of oncology, since it was postulated that tumor growth is angiogenesis dependent. Therefore, therapies that are aimed to inhibit angiogenesis are promising interventions for cancer. Imaging methods to evaluate angiogenesis are becoming increasingly important and especially the area of molecular imaging highly depends on suitable and specific contrast agents.
Nanotechnology offers the unique possibility to create nanoscale devices that can have multiple properties integrated.
In this chapter the synthesis and application of two types of nanoparticles with fluorescent and magnetic properties for multimodality imaging, i.e. magnetic resonance imaging (MRI) and optical techniques, will be discussed. The first part deals with a nanoparticle based on liposomes which was used to visualize and quantify tumor angiogenesis in vivo with MRI, after applying angiostatic therapy. The second part of this chapter focuses on a nanoparticle that is based on fluorescent quantum dots with a paramagnetic micellar coating. We demonstrate the applicability of this contrast agent for parallel intravital microscopy and MRI in vivo.
Both nanoparticles were shown to be very useful for molecular imaging of tumor angiogenesis.
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Mulder, W.J. et al. (2008). Bimodal Liposomes and Paramagnetic QD-Micelles for Multimodality Molecular Imaging of Tumor Angiogenesis. In: Bulte, J.W., Modo, M.M. (eds) Nanoparticles in Biomedical Imaging. Fundamental Biomedical Technologies, vol 102. Springer, New York, NY. https://doi.org/10.1007/978-0-387-72027-2_23
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DOI: https://doi.org/10.1007/978-0-387-72027-2_23
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