Abstract
The microvasculature of the human brain consists of approximately 400 miles of capillaries with a surface area of about 100 square feet (Pardridge, 1991). Because the capillary network in the brain is so extensive, Pardridge has suggested that “nearly every neuron is virtually perfused by its own microvessel” (Pardridge, 2002). Yet, despite this extensive surface area and the fact that the blood-brain barrier (BBB) is comprised of a cell monolayer having a thickness of only 200–300 nm, the impermeability of this barrier is widely acknowledged, and methods to circumvent it have been the subject of many reviews (Rapoport, 1976; Rapoport et al., 1979; Fenstermacher and Rapoport, 1984; Neuwelt, 1989; Pardridge, 1991, 1993, 2001; Bradbury, 1992; Drewes and Betz, 1993; Anderson, 1996).
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Anderson, B.D. (2007). Prodrug Approaches for Drug Delivery to the Brain. In: Stella, V.J., Borchardt, R.T., Hageman, M.J., Oliyai, R., Maag, H., Tilley, J.W. (eds) Prodrugs. Biotechnology: Pharmaceutical Aspects, vol V. Springer, New York, NY. https://doi.org/10.1007/978-0-387-49785-3_17
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