1. Abstract
The vitamin B6 vitamers, pyridoxine, pyridoxal and pyridoxamine are capable of promoting the mobilization of hepatic glycogen stores and hyperglycemia in the rat. These effects, which are dose-related and far greater with pyridoxal than with the other B6 vitamers, follow the outpouring of adrenomedullary catecholamines into the circulation. By taking advantage of this animal model, the present study was undertaken to examine the validity of a previously held view that taurine can suppress the release of adrenomedullary catecholamines. By treating Sprague-Dawley rats with intraperitoneal doses of pyridoxal, taurine, β-alanine, specific pharmacological antagonists (atropine, hexamethonium, labetalol, propranolol, verapamil) and their combinations, it was determined that the attenuating action of taurine on pyridoxal-induced glycogenolysis is centered in the adrenal gland.
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7. References
Brubacher, G. B., 1989, Estimation of the daily requirements for vitamins, in: Elevated Dosages of Vitamins, P. Walter, H. Stähelin, and G. Brubacher, eds., Hans Huber Publishers, Toronto, p. 10.
Kendall, B. F., 1984, An investigation of selected toxic effects of pyridoxal and pyridoxine in the Sprague-Dawley rat, Ph.D. Thesis, St. John’s University, New York.
Keppler, D. and Decker, K., 1974, Glycogen. Determination with amyloglucosidase, in: Methods of Enzymatic Analysis, vol. 3, H. U. Bergmeyer, ed., Academic Press, New York, pp. 1127–1131.
Kraft, H. G., Fiebig, L., and Hotovy, R., 1961, On the pharmacology of vitamin B6 and its derivatives, Arzneimittelforschung 11:922–929.
Kuriyama, K. and Nakagawa, K., 1976, Role of taurine in adrenal gland: a preventive effect on stress-induced release of catecholamines from c§omaffin granules, in: Taurine, R. Huxtable and A. Barbeau, eds., Raven Press, New York, pp. 335–345.
Lau-Cam, C. A., Thadikonda, K. P., and Kendall, B. F., 1991, Stimulation of rat liver glycogenolysis by vitamin B6: a role for adrenal catecholamines, Res. Commun. Chem. Pathol. Pharmacol. 73:197–207.
Lim, D.-Y., Jang, S.-J., and Park, D.-G., 2002, Comparison of catecholamine release in the isolated adrenal glands of SHR and WKY rats, Autonom. Autacoid Pharmacol. 22:225–232.
Muramatsu, M., Kakita, K., Nakagawa, K., and Kuriyama, K., 1978, A modulating role for taurine on acetylcholine and norepinephrine from neuronal tissues, Jap. J. Pharmacol. 28:259–268.
Nakagawa, K. and Kuriyama, K., 1975, Effect of taurine on alteration in adrenal functions induced by stress, Jap. J. Pharmacol. 25:737–746.
Riley, V., 1960, Adaptation of orbital bleeding technic to rapid serial blood studies, Proc. Soc. Exp. Biol. Med. 104:751–754.
Shaffer, J. E. and Kocsis, J. J., 1981, Taurine mobilizing effects of beta-alanine and other inhibitors of taurine transport, Life Sci. 28:2727–2736.
Schaumburg, H., Kaplan, J., Windebank, A., Vick, N., Rasmus, S., Pleasure, D., and Brown, M. J., 1983, Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome, New Engl. J. Med. 309:445–448.
Unna, K. R. and Honig, G. R., 1968, Vitamin B6. XII. Pharmacology and toxicology, in: The Vitamins: Chemistry, Physiology, Pathology, Methods, 2nd edn., Vol. II, W. H. Sebrell, Jr. and R. S. Harris, eds., Academic Press, New York, pp. 104–108.
Wang, Y., Fice, D. S., and Yeung, P. K., 1999, A simple high-performance liquid chromatography assay for simultaneous determination of plasma norepinephrine, epinephrine, dopamine and 3,4-dihydroxyphenyl acetic acid, J. Pharmacol. Biomed. Anal. 21:519–525.
Waterfield, C. J., Turton, J. A., Scales, M. D. C., and Timbrell, J. A., 1993, Reduction of liver taurine in rats by β-alanine treatment increases carbon tetrachloride toxicity, Toxicology 77:7–20.
Williams, C. H., Dozier, S. E., Buzello, W., Gehrke, C. W., Wong, J. K., and Gerhardt, K. O., 1985, Plasma levels of norepinephrine and epinephrine during malignant hyperthermia in susceptible pigs, J. Chromatogr. 344:71–80.
Wollenberger, A., Ristau, O., and Schoffa, G., 1960, A simple technic for extremely rapid freezing of large pieces of tissue, Pflugers Arch. Ges. Physiol. Menschen Tiere 270:399–412.
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Patel, J.P., Lau-Cam, C.A. (2006). Taurine Attenuates Pyridoxal-Induced Adrenomedullary Catecholamine Release and Glycogenolysis in the Rat. In: Oja, S.S., Saransaari, P. (eds) Taurine 6. Advances in Experimental Medicine and Biology, vol 583. Springer, Boston, MA . https://doi.org/10.1007/978-0-387-33504-9_15
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DOI: https://doi.org/10.1007/978-0-387-33504-9_15
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