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Longterm Effects of Pre- and Postnatal Exposure to Low and High Dietary Protein Levels

Evidence From Epidemiological Studies And Controlled Animal Experiments

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Early Nutrition and its Later Consequences: New Opportunities

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 569))

Abstract

The purpose of this short review is to summarize the available evidence from observational studies and rodent models for an association between maternal protein intake, birth weight, pre- and post-weaning body mass gain and adult body fatness in the offspring.

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References

  • Bennis-Taleb N, Remacle C, Hoet JJ, Reusens B, 1999, A low-protein isocaloric diet during gestation affects brain development and alters permanently cerebral cortex blood vessels in rat offspring. J Nutr. 129:1613–1619.

    PubMed  CAS  Google Scholar 

  • Campbell DM, Hall MH, Barker DJ, Cross J, Shiell AW, Godfrey KM, 1996,. Diet in pregnancy and the offspring’s blood pressure 40 years later, Br J Obstet Gynaecol. 103:273–280.

    PubMed  CAS  Google Scholar 

  • Desai M, Byrne CD, Meeran K, Martenz ND, Bloom SR, Hales CN, 1997, Regulation of hepatic enzymes and insulin levels in offspring of rat dams fed a reduced-protein diet. Am J Physiol. 273(4 Pt 1):G899–904.

    PubMed  CAS  Google Scholar 

  • Daenzer M, Daenzer M, Ortmann S, Klaus S, Metges CC, 2002, Prenatal high protein exposure decreases energy expenditure and increases adiposity in young rats. J Nutr; 132: 142–144.

    PubMed  CAS  Google Scholar 

  • Gambardella P, Sticchi R, Ferrante P, D’Aponte D, 1987, Hyper-and hypoproteic diet in growing rats: comparison between effects and evaluation of damages. Int J Vitam Nutr Res. 57:441–445.

    PubMed  CAS  Google Scholar 

  • Gardner DS, Jackson AA, Langley-Evans SC, 1997, Maintenance of maternal diet-induced hypertension in the rat is dependent on glucocorticoids. Hypertension 30:1525–1530.

    PubMed  CAS  Google Scholar 

  • Godfrey KM, Barker DJ. Fetal nutrition and adult disease, 2000, Am J Clin Nutr.; 71:1344S–1352S.

    PubMed  CAS  Google Scholar 

  • Godfrey K, Robinson S, Barker DJP, Osmond C, Cox V, 1996, Maternal nutrition in early and late pregnancy in relation to placental and fetal growth. BMJ 312:410.

    PubMed  CAS  Google Scholar 

  • Hales CN, Ozanne SE, 2003, For debate: Fetal and early postnatal growth restriction lead to diabetes, the metabolic syndrome and renal failure, Diabetologia 46:1013–1019.

    PubMed  CAS  Google Scholar 

  • Huxley R, Neil A, Collins R, 2002, Unravelling the fetal origins hypothesis: is there really an inverse association between birthweight and subsequent blood pressure? Lancet 31:360(9334):659–665.

    Google Scholar 

  • Jaquet D, Gaboriau A, Czernichow P, Levy-Marchal C, 2000, Insulin resistance early in adulthood in subjects born with intrauterine growth retardation. J Clin Endocrinol Metab. 85:1401–1406.

    PubMed  CAS  Google Scholar 

  • Kramer MS, Kakuma R, 2003, Energy and protein intake in pregnancy. Cochrane Database Syst Rev. 4:CD000032.

    Google Scholar 

  • Kramer MS, 1993, Effects of energy and protein intakes on pregnancy outcome: an overview of the research evidence from controlled clinical trials. Am J Clin Nutr. 58:627–635.

    PubMed  CAS  Google Scholar 

  • Langley-Evans SC, Langley-Evans AJ, Marchand MC, 2003, Nutritional programming of blood pressure and renal morphology. Arch Physiol Biochem. 111:8–16.

    Article  PubMed  CAS  Google Scholar 

  • Martorell R, Stein AD, Schroeder DG, 2001, Early nutrition and later adiposity. J. Nutr. 131: 874S–880S.

    PubMed  CAS  Google Scholar 

  • Mathews F, Yudkin P, Neil A, 1999, Influence of maternal nutrition on outcome of pregnancy: prospective cohort study. BMJ. 319(7206):339–343.

    PubMed  CAS  Google Scholar 

  • Metges CC, 2001, Does dietary protein in early life affect the development of adiposity in mammals? J Nutr. 131:2062–2066.

    PubMed  CAS  Google Scholar 

  • Ozanne SE, Lewis R, Jennings BJ, Hales CN, 2004, Early programming of weight gain in mice prevents the induction of obesity by a highly palatable diet. Clin Sci (Lond). 106:141–145.

    CAS  Google Scholar 

  • Rees WD, Hay SM, Buchan V, Antipatis C, Palmer RM, 1999. The effects of maternal protein restriction on the growth of the rat fetus and its amino acid supply. Br J Nutr. 81:243–250.

    PubMed  CAS  Google Scholar 

  • Shiell AW, Campbell-Brown M, Haselden S, Robinson S, Godfrey KM, Barker DJ, 2001, High-meat, low-carbohydrate diet in pregnancy: relation to adult blood pressure in the offspring. Hypertension 38:1282–1288.

    PubMed  CAS  Google Scholar 

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Metges, C.C. (2005). Longterm Effects of Pre- and Postnatal Exposure to Low and High Dietary Protein Levels. In: Koletzko, B., Dodds, P., Akerblom, H., Ashwell, M. (eds) Early Nutrition and its Later Consequences: New Opportunities. Advances in Experimental Medicine and Biology, vol 569. Springer, Dordrecht. https://doi.org/10.1007/1-4020-3535-7_11

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  • DOI: https://doi.org/10.1007/1-4020-3535-7_11

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-1-4020-3534-0

  • Online ISBN: 978-1-4020-3535-7

  • eBook Packages: MedicineMedicine (R0)

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