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Buccal Dosage Forms: General Considerations for Pediatric Patients

  • Review Article
  • Theme: Pediatric Drug Development and Dosage Form Design
  • Published:
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ABSTRACT

The development of an appropriate dosage form for pediatric patients needs to take into account several aspects, since adult drug biodistribution differs from that of pediatrics. In recent years, buccal administration has become an attractive route, having different dosage forms under development including tablets, lozenges, films, and solutions among others. Furthermore, the buccal epithelium can allow quick access to systemic circulation, which could be used for a rapid onset of action. For pediatric patients, dosage forms to be placed in the oral cavity have higher requirements for palatability to increase acceptance and therapy compliance. Therefore, an understanding of the excipients required and their functions and properties needs to be particularly addressed. This review is focused on the differences and requirements relevant to buccal administration for pediatric patients (compared to adults) and how novel dosage forms can be less invasive and more acceptable alternatives.

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ACKNOWLEDGMENTS

All authors thank the support from the STINT IB2015-6087 project. Additionally, support is acknowledged from FONDECYT 11130235 and FONDAP 15130011.

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Authors and Affiliations

  1. Department of Pharmaceutical Science and Technology, School of Chemical and Pharmaceutical Sciences, University of Chile, 8380494, Santiago, Chile

    Soledad Montero-Padilla & Javier O. Morales

  2. Department of Health Sciences, Luleå University of Technology, 97187, Luleå, Sweden

    Sitaram Velaga

  3. Advanced Center for Chronic Diseases (ACCDiS), 8380494, Santiago, Chile

    Javier O. Morales

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  1. Soledad Montero-Padilla
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  2. Sitaram Velaga
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  3. Javier O. Morales
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Correspondence to Javier O. Morales.

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Montero-Padilla, S., Velaga, S. & Morales, J.O. Buccal Dosage Forms: General Considerations for Pediatric Patients. AAPS PharmSciTech 18, 273–282 (2017). https://doi.org/10.1208/s12249-016-0567-2

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