Abstract
The aim of the present study was to investigate the potential of a phospholipid-based microemulsion formulation for parenteral delivery of anticancer drug, etoposide. The microemulsion area was identified by constructing pseudoternary phase diagrams. The prepared microemulsions were subjected to different thermodynamic stability tests. The microemulsion formulations that passed thermodynamic stability tests were characterized for optical birefringence, droplet size, viscosity measurement, and pH measurements. To assess the safety of the formulations for parenteral delivery, the formulation was subjected to compatibility studies with various intravenous infusions and in vitro erythrocyte toxicity study. The developed formulation was found to be robust and safe for parenteral delivery.
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Acknowledgments
The authors are grateful to the University Grant Commission (New Delhi, India) for providing financial support for this project. The authors are also thankful to Degussa and Abitec Corp. USA for providing the gift samples of oils, surfactants, and cosurfactants.
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Jain, J., Fernandes, C. & Patravale, V. Formulation Development of Parenteral Phospholipid-based Microemulsion of Etoposide. AAPS PharmSciTech 11, 826–831 (2010). https://doi.org/10.1208/s12249-010-9440-x
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DOI: https://doi.org/10.1208/s12249-010-9440-x