Bulletin of Experimental Biology and Medicine

, Volume 136, Issue 5, pp 474–477

Comparative Study of Action Mechanisms of Dimebon and Memantine on AMPA- and NMDA-Subtypes Glutamate Receptors in Rat Cerebral Neurons

Authors

    • Russian Academy of SciencesInstitute of Physiologically Active Substances
  • O. A. Dranyi
    • Russian Academy of SciencesInstitute of Physiologically Active Substances
  • S. O. Bachurin
    • Russian Academy of SciencesInstitute of Physiologically Active Substances
Article

DOI: 10.1023/B:BEBM.0000017097.75818.14

Cite this article as:
Grigor'ev, V.V., Dranyi, O.A. & Bachurin, S.O. Bulletin of Experimental Biology and Medicine (2003) 136: 474. doi:10.1023/B:BEBM.0000017097.75818.14

Abstract

Dimebon in low concentrations potentiated activity of AMPA-receptors in rat cerebellar Purkinje neurons, while memantine produced only an insignificant potentiation in a small group of these cells. In cortical neurons of rat brain memantine efficiently blocked NMDA-induced currents in dimebon-insensitive neurons. By contrast, its effect was far weaker in neurons, where the blocking action of dimebon on NMDA-receptors was most pronounced. It was hypothesized that the differences in the effects of memantine and dimebon are determined by their interaction with different sites of NMDA-receptors.

Alzheimer diseasememantinedimebonaction mechanismglutamate receptors

Copyright information

© Plenum Publishing Corporation 2003