Dear Reader,

As we approach the end of 2016, and publish our final issue of Clinical Pharmacokinetics for the year, we wish to reflect on another successful year for the journal and for others in the Adis Premier journals portfolio, and to thank all who have contributed to Clinical Pharmacokinetics over the past 12 months.

This year Clinical Pharmacokinetics published 105 manuscripts, including 42 review articles, in 12 issues. The ten most popular articles published this year, based on the number of full-text downloads from Springer Link (as of October 2016), are listed below:

Population Pharmacokinetic Modelling of Recombinant Factor IX Fc Fusion Protein (rFIXFc) in Patients with Haemophilia B

Lei Diao, Shuanglian Li, Thomas Ludden, Jogarao Gobburu, Ivan Nestorov, Haiyan Jiang

[http://link.springer.com/article/10.1007%2Fs40262-013-0129-7]

Pharmacokinetics and Pharmacodynamics of Edoxaban, a Non-Vitamin K Antagonist Oral

Anticoagulant that Inhibits Clotting Factor Xa

Dolly A. Parasrampuria, Kenneth E. Truitt

[http://link.springer.com/article/10.1007/s40262-015-0342-7]

Pharmacokinetic Aspects of the Two Novel Oral Drugs Used for Metastatic Castration-Resistant Prostate Cancer: Abiraterone Acetate and Enzalutamide

Guillemette E. Benoist, Rianne J. Hendriks, Peter F. A. Mulders, Winald R. Gerritsen, Diederik M. Somford, Jack A. Schalken, Inge M. van Oort, David M. Burger, Nielka P. van Erp

[http://link.springer.com/article/10.1007/s40262-016-0403-6]

Predicting Drug Extraction in the Human Gut Wall: Assessing Contributions from Drug Metabolizing Enzymes and Transporter Proteins using Preclinical Models

Sheila Annie Peters, Christopher R. Jones, Anna-Lena Ungell, Oliver J. D. Hatley

[http://link.springer.com/article/10.1007/s40262-015-0351-6]

Dosing Recommendations for Concomitant Medications During 3D Anti-HCV Therapy

Prajakta S. Badri, Jennifer R. King, Akshanth R. Polepally, Barbara H. McGovern, Sandeep Dutta, Rajeev M. Menon

[http://link.springer.com/article/10.1007/s40262-015-0317-8]

Clinical Pharmacokinetic and Pharmacodynamic Profile of Rivaroxaban

Wolfgang Mueck, Jan Stampfuss, Dagmar Kubitza, Michael Becka

[http://link.springer.com/article/10.1007/s40262-013-0100-7]

Liraglutide in Type 2 Diabetes Mellitus: Clinical Pharmacokinetics and Pharmacodynamics

Lisbeth V. Jacobsen, Anne Flint, Anette K. Olsen, Steen H. Ingwersen

[http://link.springer.com/article/10.1007/s40262-015-0343-6]

Clinical Pharmacokinetics of Therapeutic Monoclonal Antibodies

Ron J. Keizer, Alwin D. R. Huitema, Jan H. M. Schellens, Jos H. Beijnen

[http://link.springer.com/article/10.2165/11531280-000000000-00000]

Ebola Virus Infection: Review of the Pharmacokinetic and Pharmacodynamic Properties of Drugs Considered for Testing in Human Efficacy Trials

Vincent Madelain, Thi Huyen Tram Nguyen, Anaelle Olivo, Xavier de Lamballerie, Jérémie Guedj, Anne-Marie Taburet, France Mentré

[http://link.springer.com/article/10.1007/s40262-015-0364-1]

Effect of Age and Renal Function on Idarucizumab Pharmacokinetics and Idarucizumab-Mediated Reversal of Dabigatran Anticoagulant Activity in a Randomized, Double-Blind, Crossover Phase Ib Study

Stephan Glund, Joachim Stangier, Joanne van Ryn, Michael Schmohl, Viktoria Moschetti, Wouter Haazen, Marina De Smet, Dietmar Gansser, Stephen Norris, Benjamin Lang, Paul Reilly, Jörg Kreuzer

[http://link.springer.com/article/10.1007/s40262-016-0417-0]

We offer our sincere thanks to all authors who have contributed articles to Clinical Pharmacokinetics over the course of 2016. Their skill and dedication are critical to the continued publication of the journal.

Mid-2016 saw the release of the ISI Journal Citation Reports and the latest journal impact factors. The Impact Factor of Clinical Pharmacokinetics fell marginally (~4%) from 2014 to 4.829, and the journal is currently ranked 26 of 253 journals in the ‘Pharmacology & Pharmacy’ category. The majority of our other journals saw a rise in impact factor against the previous year. Most notably, five of our journals saw an increase of over 10% in impact factor—The Patient (17.08%), Clinical Drug Investigation (15.99%), the American Journal of Clinical Dermatology (13.17%), Drug Safety (13.52%), and Drugs (12.43%).

Another important milestone was reached for our recently launched open access journals, Drug Safety—Case Reports and Drugs—Real World Outcomes. Content from these journals is now available on PubMed Central.

The Adis journals portfolio will expand in 2017, with the launch of PharmacoEconomics—Open. This new journal will be fully open access and will focus on the publication of applied research on the economic implications and health outcomes associated with drugs, devices and other healthcare interventions. It joins our other well respected health outcomes publications, PharmacoEconomics, Applied Health Economics and Health Policy, and The Patient: Patient-Centered Outcomes Research.

The quality of published articles is, similarly, testament to the significant efforts of the peer reviewers, whose commitment ensures that the journal’s content is held to the highest possible standard. We would like to thank the following individuals who acted as reviewers for Clinical Pharmacokinetics in the last 12 months:

Richat Abbas, USA

Khaled Abduljalil, UK

Edward Acosta, USA

Adedayo B. Adedoyin, USA

Johannes M.F.G. Aerts, The Netherlands

Karel Allegaert, Belgium

Nicole Almenrader, Italy

Lisa M. Almond, UK

Rosalin Arends, USA

David J. Back, UK

Imke H. Bartelink, USA

Romuald Bellmann, Austria

Neal L. Benowitz, USA

Raymond L. Benza, USA

Sébastien Benzekry, France

Stacey S. Berg, USA

Troels K. Bergmann, Denmark

Julie Bertrand, France

Agnieszka Bienert, Poland

Robert R. Bies, USA

Sander Bins, The Netherlands

Michael Bloomfield, UK

Alan V. Boddy, Australia

Bruce W. Bode, USA

Markus Böhm, Germany

Sieto Bosgra, The Netherlands

Laurent Bourguignon, France

Giovanni Brandi, Italy

Simon D. Brandt, UK

Olof Breuer, Sweden

Dion R. Brocks, Canada

Roger J.M. Bruggemann, The Netherlands

Nageshwar Budha, USA

Gilbert J. Burckart, USA

Charles Burdet, France

David M. Burger, The Netherlands

Elise Burmeister Getz, USA

Howard A. Burris 3rd, USA

Andrea Calcagno, Italy

Nicholas W. Carris, USA

Dario Cattaneo, Italy

Willi Cawello, Germany

Etienne Chatelut, France

Manoranjenni Chetty, UK

Caly Chien, USA

Jaroslav Chladek, Czech Republic

Michael Christensen, USA

Uwe Christians, USA

Jae-Yong Chung, Republic of Korea

Joseph Ciccolini, France

John D. Clarke, USA

Jennifer N. Clements, USA

Lawrence J. Cohen, USA

Michael Cohen-Wolkowiez, USA

Angela P.H. Colbers, The Netherlands

Sarah F. Cook, USA

Alberto Corsini, Italy

Timothy R. Cressey, USA

Chantal Csajka, Switzerland

Albert Dahan, The Netherlands

James T. Dalton, USA

Adam S. Darwich, UK

Richard J. Davenport, UK

Peter De Boer, Belgium

Jose de Leon, USA

Maarten Deenen, The Netherlands

Marzia Del Re, Italy

Xavier Delavenne, France

Laura Dickinson, UK

Jeroen Diepstraten, The Netherlands

Thomas C. Dowling, USA

David R. Drover, USA

Janna K. Duong, Australia

Sandeep Dutta, USA

Thomas R. Easterling, USA

Andrea N. Edginton, Canada

Karel Eechoute, The Netherlands

Timothy Eley, USA

Ariane Emami Riedmaier, UK

Jean Pierre Estebe, France

Alexandre Evrard, France

Pietro Fagiolino, Uruguay

Nicola Ferri, Italy

Sergueï O. Fetissov, France

William Fissell, USA

Chris M. Florkowski, New Zealand

Christopher R. Flowers, USA

Alan K. Fotoohi, Sweden

Elizabeth Fox, USA

John H.P. Friesen, Canada

Adam Frymoyer, USA

Angelo L. Gaffo, USA

Raymond E. Galinsky, USA

James M. Gallo, USA

Alfredo Garcia-Arieta, Spain

Hans Gelderblom, The Netherlands

Eva Germovsek, Sweden

Cristina Gervasoni, Italy

Jacqueline Gibbons, USA

Stefano Giovagnoli, Italy

Paul Glue, New Zealand

Daniel Gonzalez, USA

Norbert M. Graf, Germany

Stanislas Grassin-Delyle, France

David J. Greenblatt, USA

Matthieu Grégoire, France

Rick Greupink, The Netherlands

Marina Grischenko, USA

Franjo Grotenhermen, Germany

Henk-Jan Guchelaar, The Netherlands

Neeraj Gupta, USA

Richard H. Guy, France

Tim Heise, Germany

Matthew D. Hellmann, USA

Nicholas Heming, France

Georg Hempel, Germany

Daniel Hertz, USA

Dennis A. Hesselink, The Netherlands

Jules Heuberger, The Netherlands

Anthony Hickey, USA

Nicolas Hohmann, Germany

Mads Hornum, Denmark

Seth Housman, USA

Roman Hovorka, UK

Jingbo Hu, China

Fenglei Huang, USA

Alwin D.R. Huitema, The Netherlands

Janne Hukkanen, Finland

Selwyn J. Hurwitz, USA

Paul R. Hutson, USA

Ichiro I. Ieiri, Japan

Yoji Ishida, Japan

Nina Isoherranen, USA

Janattul Ain Jamal, Malaysia

Rasmus Jansson-Löfmark, Sweden

Nicolas Janus, France

Markus Joerger, Switzerland

Trevor N. Johnson, UK

Atholl A. Johnston, UK

Daniel Jonker, Denmark

Siv Jonsson, Sweden

Vincent Jullien, France

Naoyuki Kamatani, Japan

Konstantinos Kamperis, Denmark

Marta Karaźniewicz-Łada, Poland

Sreeneeranj Kasichayanula, USA

Ron Keizer, Sweden

Tony K.L. Kiang, Canada

Dimitrios N. Kiortsis, Greece

Ty H. Kiser, USA

Richard Klein, The Netherlands

Daniel Kleinloog, The Netherlands

Gitte M. Knudsen, Denmark

Shinji Kobuchi, Japan

Elke H.J. Krekels, The Netherlands

Søren L. Kristensen, Denmark

Shaun Kumar, Australia

Hiroyuki Kusuhara, Japan

Celine Laffont, France

Yurong Lai, USA

Sophie Lancelot, France

Steven Lane, UK

Irene M. Lang, Austria

Nienke Lankheet, The Netherlands

Howard Lee, Republic of Korea

Florian Lemaitre, France

Linzhong Li, UK

Oscar Linares, USA

Jeffrey Lipman, Australia

Xiaoxi Liu, USA

Xiao-Dong Liu, China

Janel Long-Boyle, USA

Rubin Lubomirov, Spain

Johan Lundberg, Sweden

Svetlana Lyapustina, USA

Iain A.M. MacPhee, UK

Shawn H. MacVane, USA

Kazuya Maeda, Japan

Iftekhar Mahmood, USA

Naveed M. Malek, UK

Bimal Malhotra, USA

Prashanth Manda, USA

Roberto Mandrioli, Italy

Amelie Marsot, France

Kevin J. Martin, USA

Catia Marzolini, Switzerland

Roos Masereeuw, The Netherlands

Mohammed Basri Mat Nor, Malaysia

Ron A.A. Mathot, The Netherlands

Hideo Matsumoto, Japan

Catherine McCuaig, Canada

Jeannine McCune, USA

Helen McIlleron, South Africa

Susanna E. Medellin-Garibay, Mexico

Rajeev Menon, USA

Sara J. Micale, USA

Gerd Mikus, Germany

J. Alasdair Millar, Australia

Fumihiro Mizokami, Japan

Anil Modak, USA

Nishit B. Modi, USA

Dirk Jan A.R. Moes, The Netherlands

Jose Molto, Spain

Mario Monshouwer, Belgium

Joyce Mordenti, USA

Maasaki Mori, Japan

Matteo Morotti, UK

David L. Morse, USA

Sergey M. Motov, USA

Samer Moukassi, Canada

Guillaume Moulis, France

Thomas Muller, Germany

Florin M. Musteata, USA

Christa E. Nath, Australia

Thi Huyen Tram Nguyen, France

Jace Nielsen, USA

Elisabet I. Nielsen, Sweden

Cynthia M. Nijenhuis, The Netherlands

Valerie C. Nock, Germany

Dag Nyholm, Sweden

Kayode Ogungbenro, UK

Anne E. Olesen, Denmark

Mimi S. Opdal, Norway

Mehdi Oualha, France

Sivi Ouwerkerk-Mahadevan, Belgium

Angelo Paci, France

Manjunath P. Pai, USA

Jignesh P. Patel, UK

AlanS. Perelson, USA

Juan José Perez-Ruixo, Spain

Antonia Periclou, USA

Kristin C.C. Petri, Denmark

Marc Pfister, Switzerland

Mitch A. Phelps, USA

Michael Philippe, France

Italo Poggesi, Belgium

Thomas M. Polasek, Australia

Akshanth R. Polepally, USA

Miguel A. Pozo, Spain

Alessio Provenzani, Italy

Jerry Radziuk, USA

Isabelle D. Ragueneau-Majlessi, USA

Venkatesh P. Reddy, UK

Mario B. Regazzi, Italy

Julius F. Remenar, USA

Lutz Renders, Germany

Ann Rigby-Jones, UK

Jacques Robert, France

Jason A. Roberts, Australia

Claire Roger, France

Staffan Rosenborg, Sweden

Annick Rousseau, France

Malcolm M. Rowland, UK

Bernard Royer, France

Yue Ruan, UK

Frans G.M. Russel, The Netherlands

Teijo Saari, Finland

Jose A. Sachez-Alcazar, Spain

Farzaneh Salem, UK

Ahmed H. Salem, USA

Shigeru S. Satoh, Japan

Kimberly K. Scarsi, USA

André J. Scheen, Belgium

Thomas W.L. Scheeren, The Netherlands

Matthias Scheffler, Germany

Pandi-Perumal Seithikurippu Ratnas, Canada

Seyedmojtaba Seyedmousavi, The Netherlands

Dhaval K. Shah, USA

Catherine M.T. Sherwin, USA

Marco Siccardi, UK

Werner Siegmund, Germany

Joanna Sobiak, Poland

Dolors Soy, Spain

Edoardo Spina, Italy

Grazia Stagni, USA

Joseph F. Standing, UK

Clinton F. Stewart, USA

Carl-Olav Stiller, Sweden

Fabien Subtil, France

Jianguo Sun, China

Eleonora L. Swart, The Netherlands

Sherwin Sy, Brazil

Edyta Szalek, Poland

Abd A. Tahrani, UK

Chiaki Tanaka, USA

Shinji Taneda, Japan

Antoine Tarral, Switzerland

David Ternant, France

Hoai-Thu Thai, France

Iñaki F. Troconiz, Spain

Jennifer M. Trujillo, USA

Christopher C.J. Twelves, UK

Marta Ulldemolins, Spain

Saik Urien, France

Nielka van Erp, The Netherlands

Teun Van Gelder, The Netherlands

Johan G.C. van Hasselt, The Netherlands

Niels Vande Casteele, USA

Manthena V. Varma, USA

Gareth J. Veal, UK

An Vermeulen, Belgium

Alexander A. Vinks, USA

Suzanne Vosburg, USA

Paweł Wiczling, Poland

Nicolas Widmer, Switzerland

Jean-Baptiste Woillard, France

Jung Hee Woo, USA

Daniel Wright, New Zealand

Benjamin M. Wu, USA

Xu S. Xu, USA

Graeme C. Young, UK

Tian Yu, USA

Huixin Yu, The Netherlands

Francesco Zaccardi, UK

Markus Zeitlinger, Austria

Ping Zhao, USA

Ari Zimran, Israel

Athena F. Zuppa, USA

In addition, we would like to thank the members of the journal’s Honorary Editorial Board, who have acted as peer reviewers and authors, and have provided guidance on journal content, policy and processes:

Fatemeh Akhlaghi, USA

Gail D. Anderson, USA

Jos H. Beijnen, The Netherlands

Donald J. Birkett, Australia

Hans R. Brunner, Switzerland

Mei-Ling Chen, USA

Stephen J. Clarke, Australia

Marja-Liisa Dahl, Sweden

Neal M. Davies, Canada

Hartmut Derendorf, USA

C. Lindsay DeVane, USA

Stephen B. Duffull, New Zealand

Chin B. Eap, Switzerland

Hirotoshi Echizen, Japan

Erik Eliasson, Sweden

Mary H. Ensom, Canada

Albert Ferro, UK

Bruce Green, Australia

Roger W. Jelliffe, USA

Charlotte Kloft, Germany

Jörn Lötsch, Germany

Bernd Meibohm, USA

France Mentré, France

Gene D. Morse, USA

Pertti J. Neuvonen, Finland

Federico Pea, Italy

Emilio Perucca, Italy

Johannes H. Proost, The Netherlands

Michael S. Roberts, Australia

Amparo Sánchez Navarro, Spain

Domenic A. Sica, USA

Susan E. Tett, Australia

Miche Tod, France

Daniel J. Touw, The Netherlands

John N. van den Anker, Switzerland

We hope that you have found the articles published throughout 2016 to be both interesting and informative. We have appreciated the high quality of content contributed to the journal this year and we look forward to keeping you up to date with topical issues in the field of clinical pharmacokinetics in 2017.

With best wishes,

Amitabh Prakash and Anton van Rensburg