Dear Reader,

As we approach the end of 2015, and publish our final issue of Clinical Drug Investigation for the year, the editors and production staff at Adis wish to reflect on another successful year’s achievements and pay thanks to all those who have contributed their time and effort to guarantee the exceptional quality of our content.

We are delighted to have seen the conclusion of formalities surrounding the joint venture of Springer Science + Business Media with Nature Publishing Group, Palgrave Macmillan, Macmillan Education in early May. Substantial ground has already been made in the integration of business within the resulting Springer Nature company and we at Adis look eagerly toward the future, as the benefits of the collective expertise and capabilities of this company carry us forward.

The majority of our journals saw a rise in ISI impact factor against the previous year. Most notably, BioDrugs increased by 41 % to 2.989; the European Journal of Drug Metabolism and Pharmacokinetics increased 19 % to 1.563; CNS Drugs increased by 17 % to 5.113; Targeted Oncology increased 16 % to 4.000; Pediatric Drugs increased 15 % to 1.975; Drugs & Aging increased 13 % to 2.838; and Molecular Diagnosis & Therapy increased a further 12 % to 2.891, having already jumped 53 % in the preceding year. We hope to build upon these gains, once more, in 2016.

The Adis Book programme has grown substantially and 20 new titles will have been published over the course of the year. Over 50 further titles are currently in development with leading academics, internationally, and we continue to add more to the list. Our thanks, again, to all who have submitted these valuable proposals to date.

We offer our sincere thanks to all authors who have contributed articles to Clinical Drug Investigation over the course of 2015. Their skill and dedication are critical to the continued publication of the journal. The world-class quality of published articles is, similarly, testament to the significant efforts of the peer reviewers, whose commitment ensures that our content is held to the highest possible standard. In addition to the members of our Honorary Editorial Board, we would like to thank the following individuals who acted as reviewers for articles published in Clinical Drug Investigation in 2015:

Chadi Abbara, France

Takeshi Aiba, Japan

Dominick J. Angiolillo, USA

Alejandro Arana, Spain

Ozer Arican, Turkey

Isabelle Arnet, Switzerland

David Arroyo, Spain

Christian Asseburg, Sweden

Bengt Astrand, Sweden

Kostas Athanasakis, Greece

Kristopher Attwood, USA

Dilek Azkur, Turkey

Mona Bafadhel, UK

Giuseppe Barbesino, USA

Melissa L. Barker-Haliski, USA

Robert L. Barkin, USA

Alida Benfante, Italy

Martin Bergman, USA

Philippe Beutels, Belgium

Hasan Bhally, New Zealand

Luca Bianchi, Italy

Stephane Blanche, France

Anna Bonjoch, Spain

P. Brandon Bookstaver, USA

Claudio Borghi, Italy

Alberto M. Borobia, Spain

Ernesto Bosch, Spain

Raffaele Bugiardini, Italy

Núria Buil-Bruna, Spain

Luz Cánovas Martínez, Spain

Giuseppe Caminiti, Italy

Santos Castaneda, Spain

Nathorn Chaiyakunapruk, Malaysia

Hsien-Yen Chang, USA

Wen W. Chen, Taiwan, Republic of China

Thomas Cheriyan, USA

Tan-To Cheung, Hong Kong

Ann Catherine, Childress, USA

Shripad D. Chitnis, USA

Shao-Yuan Chuang, Taiwan, Republic of China

Susana Coimbra, Portugal

Valentino Conti, Italy

Pamela M. Crawford, UK

Manoj Dandekar, India

Maria Cristina De Martino, Italy

Rafael Arcesio Delgado-Ruiz, USA

Hartmut Derendorf, USA

Igor Diemberger, Italy

Yanhua Ding, China

Jasper Dingemanse, Switzerland

Ariane Dunant, France

Ronald R. Eccles, UK

Ehab S. El Desoky, Egypt

Michael Enenbach, USA

Jean Pierre Estebe, France

Steven Feldman, USA

Liang Feng, USA

Claudia Fortuny, Spain

Hitomi Fujii, Japan

Hidekatsu Fukuta, Japan

Luca Gallelli, Italy

Alessandra Gianoncelli, Italy

Leonid Gibiansky, USA

Richard Gilroy, USA

Luiza Raquel Grazziotin Lago, Brazil

Kendra J. Grubb, USA

Jordi Guitart Vela, Spain

Rong-Ping Guo, China

Helle Håkonsen, Norway

Nancy Hakooz, Jordan

Yoshiyuki Hamamoto, Japan

Anthony James Hatswell, UK

Menke H. Hazewinkel, The Netherlands

Rohan Hazra, USA

Yuxian He, China

Christian Hamilton Heidemann, Denmark

Sebastian Hinde, UK

Hasniza Zaman Huri, Malaysia

Paul R. Hutson, USA

Janus, Adler, Hyldebrandt, Norway

Wanrudee Isaranuwatchai, Canada

Yan Ji, USA

Lars Johannesen, USA

Varun Khurana, USA

Tony K. L. Kiang, Canada

Do Young Kim, Republic of Korea

Stephen J. Kim, USA

Frank Kloprogge, UK

Kazufumi Kobayashi, Japan

Christine Kohn, USA

Thitima Kongnakorn, UK

Anthony L. Kovac, USA

Hans G. Kress, Austria

Dieter D. Kunz, Germany

Jean-Daniel Lalau, France

Cecilie Johannessen Landmark, Norway

Maryse Lapeyre-Mestre, France

Ingrid Leal, The Netherlands

Michael S. Lee, USA

Marc H. Levin, USA

Thibault Lhermusier, France

Wei Li, China

Nicola Lucio Liberato, Italy

Matthias Liechti, Switzerland

Caroline Limbert, UK

Chieh-Yu Liu, Taiwan, Republic of China

Luis Lizan, Spain

Michelle Lofwall, USA

William W. Lumry, USA

Joyce Macwan, USA

Aurelio Maggio, Italy

Marek Malik, UK

Jose Eduardo Maté Sánchez de Val, Spain

Laura Matarese, USA

Aleksey Matveyenko, USA

Keith McBurnett, USA

Philip L. McCarthy, USA

Isaac Melamed, USA

Andrea Melani, Italy

Marco Menchetti, Italy

Martin C. Michel, Germany

Peter Michielsen, Belgium

Shingen Misaka, Japan

Junnosuke Miura, Japan

Hideaki Miyoshi, Japan

Jose Molto, Spain

Kenneth Todd Moore, USA

Joanna Monika Moryś, Poland

Domenico Motola, Italy

Kesara Na-Bangchang, Thailand

Mamoru Narukawa, Japan

Kemal Ornek, Turkey

Kazuhiro Ota, Japan

Amit G. Pandya, USA

Guido Parodi, Italy

Kashyap Patel, Australia

Lars Henning Pedersen, Denmark

Brent Petty, USA

Adriano Piattelli, Italy

Lancelot M. Pinto, Canada

Italo Poggesi, Belgium

Amin Polzin, Germany

Guiseppe Pugliese, Italy

Xuebin Qin, USA

Rammohan V. Rao, USA

Asia N. Rashed, UK

Markus Rauchenzauner, Austria

Nathaniel James Rhodes, USA

Roberto R. Riva, Italy

Alberto F. Rubio-Guerra, Mexico

Yoshifumi Saisho, Japan

Salvatore Salomone, Italy

Gareth J. Sanger, UK

Fabrizio Schifano, UK

Michele Sculati, Italy

Rashmi R. Shah, UK

De-Wei Shang, China

Akira Shimada, Japan

Naohito Shimoyama, Japan

Kwang-Hee Shin, Republic of Korea

Steven M. Silverstein, USA

Rachel Smith, USA

Patrício Soares-da-Silva, Portugal

Bruce S. Spinowitz, USA

Ezra Steiger, USA

Phyllis K. Stein, USA

Chris Stockmann, USA

Javed Tafreshi, USA

Mitsuyoshi Takahara, Japan

Hitoshi Takano, Japan

Azza A. G. Tantawy, Egypt

Joel Tarning, Thailand

Alberto Tedeschi, Italy

Hiroki Teragawa, Japan

Yasuo Terauchi, Japan

Hiroyuki Terawaki, Japan

Kristiina Tertti, Finland

Iñaki F. Troconiz, Spain

Francesco Trotta, Italy

Marco Tuccori, Canada

Charlotte Van Herzeele, Belgium

Robert Vander Stichele, Belgium

Louise Vedtofte, Denmark

Ignacio Velazquez-Rivera, Spain

Daniel D. Vittecoq, France

Ioannis Vlastos, Greece

Suzanne Vosburg, USA

Li Wang, China

Susan M. Webb, Spain

Kyle, J, Wilby, Qatar

Jean Wong, Canada

Christina Wu, USA

Jing Wu, China

Li Yang, China

Hiroshi Yoshida, Japan

Gaetano Zaccara, Italy

Wei Zhao, France

Hongxin Zhao, China

Yafeng Zhou, China

Hong-Hao Zhou, China

Mingxin Zuo, USA

We hope that you have found the articles published throughout 2015 to be both interesting and informative. The editors have appreciated the high quality of content contributed to the journal this year and look forward to keeping you up to date with topical issues in drug treatment in 2016.

With best wishes from the staff of Clinical Drug Investigation and all at Adis Publications.