Drug Delivery and Translational Research

, Volume 3, Issue 1, pp 16–25

High efficiency intranasal drug delivery using Intravail® alkylsaccharide absorption enhancers

Review Article

DOI: 10.1007/s13346-012-0069-z

Cite this article as:
Maggio, E.T. & Pillion, D.J. Drug Deliv. and Transl. Res. (2013) 3: 16. doi:10.1007/s13346-012-0069-z
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Abstract

A new class of alkylsaccharide transmucosal delivery enhancement agents are described that overcome the principal limitations preventing broad acceptance of intranasal administration for many potential applications in systemic drug delivery, namely, poor transmucosal absorption and damage to the nasal mucosa. This review will describe recent developments in use of these excipients in human clinical trials and preclinical studies along with their chemical and pharmacological properties and explore commercial implications of the use of these excipients in introduction of new intranasal formulations of peptidic and nonpeptidic drugs.

Keywords

Intranasal Intravail® Alkylsaccharide Drug delivery Polysorbate Peptide Protein aggregation 

Copyright information

© Controlled Release Society 2012

Authors and Affiliations

  1. 1.Aegis Therapeutics, LLCSan DiegoUSA
  2. 2.University of Alabama at BirminghamBirminghamUSA

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