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Altered Gray Matter Volume in Stable Chronic Obstructive Pulmonary Disease with Subclinical Cognitive Impairment: an Exploratory Study

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Abstract

Gray matter volume deficits have been identified in cognitively impaired patients with chronic obstructive pulmonary disease (COPD). However, it remains unknown whether the gray matter volume is altered in COPD patients with subclinical cognitive impairment. To determine whether any gray matter abnormalities are present in these patients, neuropsychological tests and structural MRI data were analyzed from 60 patients with COPD and 60 age-, gender-, education-, and handedness-matched normal controls (NCs). The COPD patients had similar Mini-Mental State Examination (MMSE) scores compared with the NCs. However, they had reduced Montreal Cognitive Assessment (MoCA) scores for visuospatial and executive and naming and memory functions (P < 0.001). Voxel-based morphometry (VBM) analysis revealed that the COPD patients had significantly lowered gray matter volumes in several brain regions, including the left precuneus (PrCU), bilateral calcarine (CAL), right superior temporal gyrus/middle temporal gyrus (STG/MTG), bilateral fusiform gyrus (FG), and right inferior parietal lobule (IPL) (P < 0.01, corrected). Importantly, the forced vital capacity (FVC) was found to be associated with the gray matter volume in the calcarine. The present study confirmed that brain structural changes were present in stable COPD patients with subclinical cognitive impairment. These findings may provide new insights into the pathogenesis of COPD.

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Acknowledgements

The authors thank Dr. Jiming Chen at department of respiration Nanshan Hospital Affiliated to Guangdong Medical College for Case collection and Dr. Weitu Li and Yang Yang at Guangdong Medical University for MRI data scan and neuropsychological tests.

Author Contributions

Chunrong Wang, Jie An, Kewen Peng, Gangqiang Hou, and Mei Jiang collected the data. Chunrong Wang and Yanghui Ding analyzed the data and wrote the manuscript. Shijun Qiu had the major responsibility for preparing the paper. Shijun Qiu, Bixian Shen, Dehong Gao, and Liqiu Zou supervised the project.

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Authors and Affiliations

  1. Department of Radiology, Nanfang Hospital Affiliated to Southern Medical University, Guangzhou, Guangdong, 510515, China

    Chunrong Wang & Shijun Qiu

  2. Department of Radiology, Nanshan Hospital Affiliated to Guangdong Medical University, Shenzhen, Guangdong, 518052, China

    Chunrong Wang, Bixian Shen, Dehong Gao, Kewen Peng, Gangqiang Hou, Liqiu Zou & Mei Jiang

  3. School of Information Science and Engineering, Shandong Normal University, Jinan, Shandong, 250014, China

    Yanhui Ding

  4. Department of Radiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510405, China

    Jie An & Shijun Qiu

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  1. Chunrong Wang
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Correspondence to Shijun Qiu.

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The present study is supported by the National Natural Science Foundation of China (Grant Nos. 81271389, 81471251, and 81571062).

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Anyone who wants to use the data for further analysis, please contact: Dr. Chunrong Wang (crwang@yahoo.com) or Prof. Shijun Qiu (qiu-sj@163.com).

Chunrong Wang and Yanhui Ding have made equal contributions to this work and should be regarded as joint first authors.

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Wang, C., Ding, Y., Shen, B. et al. Altered Gray Matter Volume in Stable Chronic Obstructive Pulmonary Disease with Subclinical Cognitive Impairment: an Exploratory Study. Neurotox Res 31, 453–463 (2017). https://doi.org/10.1007/s12640-016-9690-9

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