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Is Acrylate Co-monomer (Glubran-2) Useful in the Prevention of Prolonged Air Leaks After Pulmonary Lobectomy?

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Abstract

Many synthetic materials are being used in order to reduce the frequency of prolonged air leak (PAL) in thoracic surgical practice. This study presents our experience with the topical application of acrylate co-monomer (Glubran-2) as a synthetic tissue adhesive in an attempt to decrease troublesome postoperative air leaks in patients undergoing resection for non-small cell lung carcinoma. Of the 112 patients who had undergone resection for lung carcinoma, 69 patients having lobectomy or bilobectomy were included in this study. The application group (group A) consisted of 33 patients where a synthetic tissue adhesive (Glubran-2) was used and compared with the control group (group C, n = 36) retrospectively. There was no difference between the groups regarding demographic details and operative variables. Both groups were compared in view to PAL, chest tube duration, in-hospital stay and hospital costs. There was no significant difference between group A (n = 11, 33 %) and group C (n = 6, 17 %) for the development of PAL (P = 0.11). Hospital stay was 16.1 ± 6.7 days in group A and 15.3 ± 5.8 days in group C (P = 0.66). The surgical cost was significantly higher in group A (€806 ± 127) than the group C (€624 ± 94) (P < 0.001). There was no significant difference between the groups regarding overall hospital costs (P = 0.41). In this study, the use of Glubran-2 following lung resection for non-small cell lung carcinoma did not decrease the incidence of PAL. Neither did it have a favorable effect concerning in-hospital stay nor did it decrease overall hospital costs while increasing surgical costs as expected.

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References

  1. Cerfolio RJ, Bass CS, Pask AH et al (2002) Predictors and treatment of persistent air leaks. Ann Thorac Surg 73:1727–1731

    Article  PubMed  Google Scholar 

  2. Cerfolio RJ, Tummala RP, Holman WL et al (1998) A prospective algorithm for the management of air leaks after pulmonary resection. Ann Thorac Surg 66:1726–1731

    Article  PubMed  CAS  Google Scholar 

  3. Ohri SK, Oswal SK, Townsend ER et al (1992) Early and late outcome after diagnostic thoracoscopy and talk pleurodesis. Ann Thorac Surg 53:1038–1041

    Article  PubMed  CAS  Google Scholar 

  4. Abolhoda A, Liu D, Brooks A et al (1998) Prolonged air leak following radical upper lobectomy: an analysis of incidence and possible risk factors. Chest 113:1507–1510

    Article  PubMed  CAS  Google Scholar 

  5. Wain JC, Kaiser LR, Johnstone DW et al (2001) Trial of a novel synthetic sealant in preventing air leaks after lung resection. Ann Thorac Surg 71:1623–1629

    Article  PubMed  CAS  Google Scholar 

  6. Porte HL, Janny T, Akkad R et al (2001) Randomized controlled trial of a synthetic sealant for preventing alveolar air leaks after lobectomy. Ann Thorac Surg 71:1618–1622

    Article  PubMed  CAS  Google Scholar 

  7. Allen MS, Wood DE, Hawkinson RW et al (2004) Prospective randomized study evaluating a biodegradable polymeric sealant for sealing intraoperative air leaks that occur during pulmonary resection. Ann Thorac Surg 77:1792–1801

    Article  PubMed  Google Scholar 

  8. Lang G, Csekeo A, Stamatis G et al (2004) Efficacy and safety of topical application of human fibrinogen/thrombin-coated collagen patch (TachoComb) for treatment of air leakage after standard lobectomy. Eur J Cardiothorac Surg 25:160–166

    Article  PubMed  Google Scholar 

  9. Belboul A, Dernevik L, Aljassim O et al (2004) The effect of autologous fibrin sealant (Vivostat) on morbidity after pulmonary lobectomy: A prospective randomised, blinded study. Eur J Cardiothorac Surg 26:1187–1191

    Article  PubMed  Google Scholar 

  10. McKenna RJ, Fischel RJ, Brenner M et al (1996) Use of the Heimlich valve to shorten hospital stay after lung reduction surgery for emphysema. Ann Thorac Surg 61:1115–1117

    Article  PubMed  Google Scholar 

  11. Ponn RB, Silverman HJ, Federico JA (1997) Outpatient chest tube management. Ann Thorac Surg 64:1437–1440

    Article  PubMed  CAS  Google Scholar 

  12. Lodi R, Stefani A (2000) A new portable chest drainage device. Ann Thorac Surg 69:998–1001

    Article  PubMed  CAS  Google Scholar 

  13. Rieger MK, Wroblewski AH, Brooks AJ et al (2007) Postoperative outpatient chest tube management: initial experience with a new portable system. Ann Thorac Surg 84:630–632

    Article  PubMed  Google Scholar 

  14. Irshad K, Feldman LS, Chu VF et al (2002) Causes of increased length of hospitalization on a general thoracic surgery service: a prospective observational study. Can J Surg 45(4):264–268

    PubMed  Google Scholar 

  15. Belda-Sanchis J, Serra-Mitjans M, Iglesias Sentis M, Rami R (2010) Surgical sealant for preventing air leaks after pulmonary resections in patients with lung cancer. Cochrane Database Syst Rev 20;(1):CD003051

    PubMed  Google Scholar 

  16. Gündoğdu AG, Yazıcıoğlu A, Kara M et al (2006) The use of tissue glue and its effect on hospital cost in patients undergoing pulmonary surgery. Tuberk Toraks 54(2):157–160

    PubMed  Google Scholar 

  17. Anegg U, Lindenmann J, Matzi V et al (2007) Efficiency of fleece-bound sealing (TachoSil) of air leaks in lung surgery: a prospective randomised trial. Eur J Cardiothorac Surg 31:198–202

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Thoracic Surgery, Faculty of Medicine, Çanakkale Onsekiz Mart University, Terzioglu Yerleskesi, 17000, Çanakkale, Turkey

    Timuçin Alar

  2. Department of Thoracic Surgery, Izmir Chest Disease and Thoracic Surgery Training Hospital, Izmir, Turkey

    Kenan Can Ceylan, Elif Duman, Ozan Usluer & Oktay Başok

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  1. Timuçin Alar
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  2. Kenan Can Ceylan
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  3. Elif Duman
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  4. Ozan Usluer
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  5. Oktay Başok
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Correspondence to Timuçin Alar.

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Alar, T., Ceylan, K.C., Duman, E. et al. Is Acrylate Co-monomer (Glubran-2) Useful in the Prevention of Prolonged Air Leaks After Pulmonary Lobectomy?. Indian J Surg 75, 373–376 (2013). https://doi.org/10.1007/s12262-012-0522-8

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  • DOI: https://doi.org/10.1007/s12262-012-0522-8

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