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Prediction of clinical outcome by controlling nutritional status (CONUT) before allogeneic hematopoietic stem cell transplantation in myeloid malignancies

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Abstract

Malnutrition before allogeneic hematopoietic cell transplantation (allo-HCT) is associated with poor clinical outcomes. Herein, we evaluated the predictive value of controlling nutritional status (CONUT) in patients undergoing allo-HCT for myeloid malignancies. We retrospectively analyzed 200 patients with myeloid malignancies who underwent allo-HCT for the first time. We evaluated CONUT before the initiation of conditioning and compared malnourished patients (poor CONUT, n = 56) with non-malnourished patients (normal CONUT, n = 144). The cumulative incidence of non-relapse mortality within 100 days (early NRM) was significantly higher in the poor CONUT group than in the normal CONUT group [21.4% (95% CI: 11.8–33.0%) vs. 9.7% (95% CI: 5.6–15.2%); P = 0.025]. In multivariate analysis, poor CONUT was an independent and significant risk factor for early NRM [HR: 2.2 (95% CI: 1.0–4.7); P = 0.048]. The overall 1-year survival rate was significantly lower in the poor CONUT group than in the normal CONUT group [53.3% (95% CI: 39.4–65.4%) vs. 71.0% (95% CI: 62.7–77.7%); P = 0.005]. These findings suggest that CONUT before allo-HCT is a useful predictor of poor outcomes in patients with myeloid malignancies.

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Acknowledgements

This research was founded by Japanese Red Cross Nagoya 1st. Hospital Research Grant NFRCH19-0002. We thank the medical, nursing, and clinical staffs for their important contributions to this study and their dedicated care of the patients.

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Authors and Affiliations

  1. Department of Hematology, Japanese Red Cross Nagoya First Hospital, 3-35 Michishita-cho, Nakamura-ku, Nagoya, Japan

    Hiroaki Araie, Yuka Kawaguchi, Motohito Okabe, Yoonha Lee, Marie Ohbiki, Masahide Osaki, Miyo Goto, Tatsunori Goto, Takanobu Morishita, Yukiyasu Ozawa & Koichi Miyamura

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  1. Hiroaki Araie
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  2. Yuka Kawaguchi
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  3. Motohito Okabe
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  4. Yoonha Lee
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  5. Marie Ohbiki
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  6. Masahide Osaki
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  7. Miyo Goto
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  8. Tatsunori Goto
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  10. Yukiyasu Ozawa
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  11. Koichi Miyamura
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Correspondence to Hiroaki Araie.

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Araie, H., Kawaguchi, Y., Okabe, M. et al. Prediction of clinical outcome by controlling nutritional status (CONUT) before allogeneic hematopoietic stem cell transplantation in myeloid malignancies. Int J Hematol 110, 599–605 (2019). https://doi.org/10.1007/s12185-019-02723-w

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  • DOI: https://doi.org/10.1007/s12185-019-02723-w

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