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Hematopoietic stem cell transplantation in children and adolescents with relapsed or refractory B-cell non-Hodgkin lymphoma

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Abstract

We undertook a retrospective study using the national registry data of hematopoietic stem cell transplantation (HSCT) in Japan to investigate the effect of graft source, particularly autologous or allogeneic tissue, on the treatment outcome in patients aged less than 18 years with relapsed or refractory B-cell non-Hodgkin lymphoma (B-NHL). Survival analysis was conducted on 31 autologous HSCT (auto-HSCT) and 48 allogeneic HSCT (allo-HSCT) recipients between 1990 and 2013. The 5-year survival rates were significantly lower for allo-HSCT compared to auto-HSCT recipients (32% vs. 55%; P = 0.036). Multivariate analysis of survival rates identified allogeneic graft, Burkitt histology, and lack of response to chemotherapy as poor prognostic factors for survival. The cumulative incidence of treatment-related mortality (TRM) was significantly higher in allo-HSCT compared to auto-HSCT recipients (P = 0.017), explaining the difference in survival rates. In patients with Burkitt lymphoma (BL), overall survival was significantly inferior in the group of patients undergoing HSCT within 12 months from the initial diagnosis (P = 0.039). These data indicate that treatment outcomes for HSCT in children and adolescents with B-NHL were better in autograft recipients, suggesting that greater attention should be paid to the risk of TRM, especially after allografts, for patients with BL.

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Author information

Authors and Affiliations

  1. Department of Pediatrics, Hiroshima Red Cross Hospital and Atomic-bomb Survivors Hospital, 1-9-6 Senda-Machi, Naka-ku, Hiroshima, 730-8619, Japan

    Naoto Fujita

  2. Department of Pediatrics, Sapporo Hokuyu Hospital, Sapporo, Japan

    Ryoji Kobayashi

  3. Japanese Data Center for Hematopoietic Cell Transplantation, Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan

    Yoshiko Atsuta

  4. Department of Hematology, Kanagawa Children’s Medical Center, Yokohama, Japan

    Fuminori Iwasaki

  5. Department of Oncology/Hematology, Shimane University Hospital, Izumo, Japan

    Junji Suzumiya

  6. Department of Pediatrics, Tohoku University Graduate School of Medicine, Sendai, Japan

    Yoji Sasahara

  7. Department of Hematology/Oncology, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka, Japan

    Masami Inoue

  8. Department of Hematology/Oncology, Saitama Children’s Medical Center, Saitama, Japan

    Katsuyoshi Koh

  9. Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo, Japan

    Tsukasa Hori

  10. Division of Hemato-Oncology/Regenerative Medicine, Kanagawa Children’s Medical Center, Yokohama, Japan

    Hiroaki Goto

  11. Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan

    Tatsuo Ichinohe

  12. Pediatrics, Osaka University Graduate School of Medicine, Osaka, Japan

    Yoshiko Hashii

  13. Department of Hematology and Oncology, Children’s Medical Center, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan

    Koji Kato

  14. Department of Oncology and Hematology, Shimane University Hospital Cancer Center, Izumo, Japan

    Ritsuro Suzuki

  15. Department of Pediatrics, Yamagata University School of Medicine, Yamagata, Japan

    Tetsuo Mitsui

Authors
  1. Naoto Fujita
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  2. Ryoji Kobayashi
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  3. Yoshiko Atsuta
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  4. Fuminori Iwasaki
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  5. Junji Suzumiya
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  8. Katsuyoshi Koh
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  9. Tsukasa Hori
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  10. Hiroaki Goto
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  11. Tatsuo Ichinohe
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  13. Koji Kato
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  14. Ritsuro Suzuki
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  15. Tetsuo Mitsui
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Correspondence to Naoto Fujita.

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Fujita, N., Kobayashi, R., Atsuta, Y. et al. Hematopoietic stem cell transplantation in children and adolescents with relapsed or refractory B-cell non-Hodgkin lymphoma. Int J Hematol 109, 483–490 (2019). https://doi.org/10.1007/s12185-019-02608-y

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  • DOI: https://doi.org/10.1007/s12185-019-02608-y

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