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Risk factors and survival impact of readmission after single-unit cord blood transplantation for adults

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Abstract

Hospital readmissions have been used as a prognostic indicator for patients receiving allogeneic hematopoietic cell transplantation (HCT). However, the impact of readmission during early and mid-phase of cord blood transplantation (CBT) on long-term outcomes has not been fully investigated. We retrospectively analyzed 156 adult patients who received single-unit CBT in our institute. Among this cohort, thirteen patients (8%) were readmitted within 30 days after discharge, and 27 (17%) were readmitted within 90 days after discharge. The most common causes for readmission within 30 and 90 days of discharge were infection, chronic graft-versus-host disease, and relapse. Higher cryopreserved cord blood CD34+ cell count was only significantly associated with lower readmission within 90 days after discharge. The probabilities of overall survival were significantly lower in patients readmitted within 90 days after discharge compared with those who were not readmitted within 90 days after discharge in univariate and multivariate analysis. These data suggest that readmission within 90 days after discharge may have a significant impact on long-term mortality after single-unit CBT.

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Acknowledgements

The authors thank all of the physicians and staff at the hospital and the cord blood banks in Japan for their help in this study.

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Author notes

  1. Yasuko Yamagishi, Takaaki Konuma, Yoriko Miwa contributed equally to this work.

Authors and Affiliations

  1. Department of Nursing, Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

    Yasuko Yamagishi, Yoriko Miwa, Hatsuko Narita & Koji Kobayashi

  2. Department of Hematology/Oncology, The Institute of Medical Science, The University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan

    Takaaki Konuma, Maki Oiwa-Monna, Susumu Tanoue, Masamichi Isobe, Koji Jimbo, Mai Mizusawa, Seiko Kato, Satoshi Takahashi & Arinobu Tojo

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  1. Yasuko Yamagishi
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Correspondence to Takaaki Konuma.

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Yamagishi, Y., Konuma, T., Miwa, Y. et al. Risk factors and survival impact of readmission after single-unit cord blood transplantation for adults. Int J Hematol 109, 115–124 (2019). https://doi.org/10.1007/s12185-018-2539-7

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  • DOI: https://doi.org/10.1007/s12185-018-2539-7

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