Abstract
We describe a patient who presented with large cardiac diffuse large B-cell lymphoma (DLBCL) and adrenal masses. The patient also had subcutaneous intravascular lymphoma lesions which were detected by random skin biopsy. Although ambiguous, minimal extravascular location of lymphoma cells is permitted for the diagnosis of intravascular large B-cell lymphoma (IVLBCL) in the WHO definition, a number of rare cases have been reported as having concomitant tumours in other organs, such as the adrenal gland, brain, and penis. We assume that IVLBCL might be a peculiar feature of DLBCL characterised by preferential localisation of lymphoma cells within the capillaries rather than a distinct disease entity of DLBCL.
Similar content being viewed by others
References
O’Mahony D, Peikarz RL, Bandettini WP, Arai AE, Wilson WH, Bates SE. Cardiac involvement with lymphoma: a review of the literature. Clin Lymphoma Myeloma. 2008;8(4):249–52.
Ferreri AJ, Campo E, Seymour JF, Willemze R, Ilariucci F, Ambrosetti A, et al. Intravascular lymphoma: clinical presentation, natural history, management and prognostic factors in a series of 38 cases, with special emphasis on the ‘cutaneous variant’. Br J Haematol. 2004;127(2):173–83.
Matsue K, Asada N, Takeuchi M, Yamakura M, Kimura S, Odawara J, et al. A clinicopathological study of 13 cases of intravascular lymphoma: experience in a single institution over a 9-yr period. Eur J Haematol. 2008;80(3):236–44.
Fukushima A, Okada Y, Tanikawa T, Onaka T, Tanaka A, Higashi T, et al. Primary bilateral adrenal intravascular large B-cell lymphoma associated with adrenal failure. Intern Med. 2003;42(7):609–14.
Asada N, Odawara J, Kimura S, Aoki T, Yamakura M, Takeuchi M, et al. Use of random skin biopsy for diagnosis of intravascular large B-cell lymphoma. Mayo Clin Proc. 2007;82(12):1525–7.
Shanmugam G. Primary cardiac sarcoma. Eur J Cardiothorac Surg. 2006;29(6):925–32.
Matsue K, Asada N, Odawara J, Aoki T, Kimura S, Iwama K, et al. Random skin biopsy and bone marrow biopsy for diagnosis of intravascular large B cell lymphoma. Ann Hematol. 2011;90(4):417–21.
Matsue K, Hayama BY, Iwama K, Koyama T, Fujiwara H, Yamakura M, et al. High frequency of neurolymphomatosis as a relapse disease of intravascular large B-cell lymphoma. Cancer. 2011;117(19):4512–21.
Souza CA, Quan K, Seely J, Kravcik S, Burns B. Pulmonary intravascular lymphoma. J Thorac Imaging. 2009;24(3):231–3.
Zhao XF, Sands AM, Ostrow PT, Halbiger R, Conway JT, Bagg A. Recurrence of nodal diffuse large B-cell lymphoma as intravascular large B-cell lymphoma: is an intravascular component at initial diagnosis predictive? Arch Pathol Lab Med. 2005;129(3):391–4.
Katz DA, Miller IJ, Gregory SA. Intravascular B-cell lymphoma following nodal diffuse large B-cell lymphoma. Clin Adv Hematol Oncol. 2010;8(9):637–41.
Thomas CA, Guileyardo JM, Krause JR. An intravascular lymphoma with extravascular tendencies. Proc (Bayl Univ Med Cent). 2014;27(4):341–3.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
All authors have no conflict of interest.
About this article
Cite this article
Abe, Y., Usui, Y., Narita, K. et al. Concomitant subcutaneous intravascular lymphoma lesions in a patient with cardiac diffuse large B-cell lymphoma: is intravascular lymphoma a distinct clinical entity?. Int J Hematol 108, 637–639 (2018). https://doi.org/10.1007/s12185-018-2532-1
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12185-018-2532-1