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Autologous hematopoietic stem cell transplantation may improve long-term outcomes in patients with newly diagnosed extranodal natural killer/T-cell lymphoma, nasal type: a retrospective controlled study in a single center

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Abstract

Extranodal natural killer/T-cell lymphoma, nasal type (ENKTL) is a rare disease with a poor prognosis. The long-term effect of autologous hematopoietic stem cell transplantation (auto-HSCT) on ENKTL has been reported occasionally but needs further investigation. In this retrospective study from a single center, 20 ENKTL patients who received induction chemotherapy followed by auto-HSCT ± involved-field radiotherapy (IFRT) ± additional chemotherapy were enrolled as a study group. Another 60 fit ENKTL patients who received induction chemotherapy ± IFRT ± additional chemotherapy were selected as the control group. Baseline characteristics of all patients were well balanced. Our analysis showed that after a median follow-up time of 61.0 months (95% CI 52.3–69.7), the auto-HSCT treated group showed better overall survival (OS) than the control group (p = 0.045). The median OS of the auto-HSCT-treated group was not reached, but that of the control group was 62.0 months. Five-year comparison of OS between the two groups also showed a significant difference (79.3 vs. 52.3%, p = 0.026). We suggest that auto-HSCT treatment, in combination with chemoradiotherapy, may prolong OS and improve the long-term outcomes of fit patients with ENKTL compared to treatment with chemoradiotherapy alone.

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Authors and Affiliations

  1. Department of Hematology, Beijing Tongren Hospital, Capital Medical University, Dong Jiao Min Xiang Street, No.1, Dong Cheng District, Beijing, 10073, China

    Jingwen Wang, Liqiang Wei, Jin Ye, Lei Yang, Xin Li, Jia Cong, Na Yao, Xueying Cui, Yiping Wu, Jing Ding & Le Zhang

  2. Beijing Key Laboratory of Head and Neck Molecular Diagnostic Pathology, Dong Jiao Min Xiang Street, No.1, Dong Cheng District, Beijing, 10073, China

    Jingwen Wang, Liqiang Wei, Jin Ye, Lei Yang, Xin Li, Jia Cong, Na Yao, Xueying Cui, Yiping Wu, Jing Ding & Le Zhang

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  1. Jingwen Wang
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  2. Liqiang Wei
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  3. Jin Ye
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  4. Lei Yang
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  5. Xin Li
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  7. Na Yao
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  11. Le Zhang
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Corresponding author

Correspondence to Jingwen Wang.

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Funding

This study was supported by Beijing Municipal Science & Technology Commission No. Z151100004015089.

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The authors declare that they have no conflict of interest.

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Wang, J., Wei, L., Ye, J. et al. Autologous hematopoietic stem cell transplantation may improve long-term outcomes in patients with newly diagnosed extranodal natural killer/T-cell lymphoma, nasal type: a retrospective controlled study in a single center. Int J Hematol 107, 98–104 (2018). https://doi.org/10.1007/s12185-017-2324-z

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  • DOI: https://doi.org/10.1007/s12185-017-2324-z

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