Abstract
Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of diffuse large B-cell lymphoma (DLBCL). It commonly presents with a variety of symptoms due to occlusion of small vessels by tumor cells in different organ systems. Clinically patients may present with generalized symptoms such as fever and malaise. In western patients, there is a ‘cutaneous variant’ of IVLBCL, which demonstrates cutaneous involvement only. However, Asian patients show hemophagocytosis, which is typical of the ‘Asian variant’. Here we report a case of IVLBCL in a Chinese individual who presented with a huge mass in the subcutis of the abdomen.
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References
Sawa N, Ubara Y, Katori H, et al. Renal intravascular large B-cell lymphoma localized only within peritubular capillaries. Report of a case. Intern Med. 2007;46:657–62.
Ponzoni M, Ferreri AJ, Campo E, et al. Definition, diagnosis, and management of intravascular large B-cell lymphoma: proposals and perspectives form an international consensus meeting. J Clin Oncol. 2007;25:3168–73.
Ferreri AJ, Campo E, Seymour JF, et al. Intravascular lymphoma: clinical presentation, natural history, management and prognostic factors in a series of 38 cases, with special emphasis on the ‘cutaneous variant’. Br J Haematol. 2004;127:173–83.
Ferreri AJ, Dognini GP, Campo E, et al. Variations in clinical presentation, frequency of hemophagocytosis and clinical behavior of intravascular lymphoma diagnosed in different geographical regions. Haematologica. 2007;92:486–92.
Murase T, Nakamura S, Kawauchi K, et al. An Asian variant of intravascular large B-cell lymphoma: clinical, pathological and cytogenetic approaches to diffuse large B-cell lymphoma associated with haemophagocytic syndrome. Br J Haematol. 2000;111:826–34.
Hans CP, Weisenburger DD, Greiner TC, et al. Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray. Blood. 2004;103:275–82.
Vieren M, Sciot R, Robberecht W. Intravascular lymphomatosis of the brain: a diagnostic problem. Clin Neurol Neurosurg. 1999;101:33–6.
Gatter KC, Warnke RA. Intravascular large B-cell lymphoma. In: Jaffe ES, Harris NL, Stein H, et al., editors. Pathology and genetics of tumours of haematopoietic and lymphoid tissues. Lyon, France: IARC Press; 2001. p. 177–8.
Murase T, Yamaguchi M, Suzuki R, et al. Intravascular large B-cell lymphoma (IVLBCL): a clinicopathologic study of 96 cases with special reference to the immunophenotypic heterogeneity of CD5. Blood. 2007;109:478–85.
Ferreri AJ, Campo E, Ambrosetti A, et al. Anthracycline-based chemotherapy as primary treatment for intravascular lymphoma. Ann Oncol. 2004;15:1215–21.
Shimizu I, Ichikawa N, Yotsumoto M, et al. Asian variant of intravascular lymphoma: aspects of diagnosis and the role of rituximab. Int Med. 2007;46:1381–6.
Rashid R, Johnson RJ, Morris S, et al. Intravascular large B-cell lymphoma associated with a near-tetraploid karyotype, rearrangement of BCL6, and a t(11;14)(q13;q32). Cancer Genet Cytogenet. 2006;171:101–4.
Mandle AK, Savvidou L, Slater RM, et al. Angiotropic lymphoma: associated chromosomal abnormalities. Eur J Int Med. 2007;18:432–4.
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We would like to thank Dr. Michael A. McNutt for reviewing and correcting the manuscript.
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Wenjuan Yin, Min Li are contributed equally to this work.
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Yin, W., Li, M., Gao, Z. et al. Intravascular large B-cell lymphoma with involvement of the abdominal subcutis: a case report and literature review. Int J Hematol 89, 348–351 (2009). https://doi.org/10.1007/s12185-009-0262-0
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DOI: https://doi.org/10.1007/s12185-009-0262-0