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Association between CCNE1 polymorphisms and the risk of breast cancer in a sample of southeast Iranian population

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Abstract

Cyclin E1 (CCNE1) is a key proto-oncogene. The present study aimed to investigate the effects of single nucleotide polymorphisms in CCNE1 on the risk of breast cancer (BC) in an Iranian population in southeast of Iran. A total of 491 subjects including 266 BC patients and 225 healthy control women were participated in the study. Genotyping of CCNE1 rs3218073 and 72010703 polymorphisms was done using allele-specific polymerase chain reaction (AS-PCR) and rs1406 by PCR–RFLP method.Our findings showed that rs1406 C/A polymorphism increased the risk of BC in codominant (OR 1.60, 95 % CI 1.05–2.43, p = 0.032 CA vs CC; OR 2.35, 95 % CI 1.23–4.49, p = 0.011 AA vs CC) and dominant (OR 1.69, 95 % CI 1.22–2.56, p = 0.012 CA + AA vs CC) inheritance models. The rs1406 A allele increased the risk of BC (OR 1.37, 95 % CI 1.06–1.76, p = 0.019) in comparison with C allele. On the other hand, CCNE1 rs72010703 (4-bp I/D) and rs3218073 polymorphisms did not show any significant association with BC. This study indicates that CCNE1 rs1406 polymorphism may contribute to BC risk.

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Acknowledgments

This paper was funded as dissertation Grant (MSc thesis of SA) from the deputy for Research, Zahedan University of Medical Sciences. University of Manitoba start up funding supported SG.

Conflict of interest

The authors declare that there is no conflict of interest to disclose.

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Authors and Affiliations

  1. Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran

    Shadi Amininia & Mohammad Hashemi

  2. Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

    Shadi Amininia, Mohammad Hashemi & Mahboubeh Ebrahimi

  3. Department of Internal Medicine, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

    Mohammad Ali Mashhadi & Seyed Mehdi Hashemi

  4. Genetic of Non-communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran

    Mohsen Taheri

  5. Department of Human Anatomy and Cell Science, Faculty of Health Sciences, Manitoba Institute of Child Health, College of Medicine, University of Manitoba, Winnipeg, MB, Canada

    Saeid Ghavami

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  1. Shadi Amininia
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  2. Mohammad Hashemi
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  3. Mahboubeh Ebrahimi
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  4. Mohammad Ali Mashhadi
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  5. Seyed Mehdi Hashemi
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Correspondence to Mohammad Hashemi.

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Amininia, S., Hashemi, M., Ebrahimi, M. et al. Association between CCNE1 polymorphisms and the risk of breast cancer in a sample of southeast Iranian population. Med Oncol 31, 189 (2014). https://doi.org/10.1007/s12032-014-0189-z

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  • DOI: https://doi.org/10.1007/s12032-014-0189-z

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