Abstract
The association between gene polymorphisms of IFRD1 and gastric cancer is not clear. The aim of this study was to investigate the association between IFRD1 polymorphisms and gastric cancer in Chinese population. Fifty-three consecutive patients with the diagnosis of gastric cancer were defined as the case group, and another 50 healthy donors were denoted as the control group. About 4 ml of peripheral blood was collected from each donor for extracting DNA. Finally, IFRD1 rs7818, rs3807213, and rs6968084 SNPs were detected with polymerase chain reaction. C/C genotype distribution frequencies of rs6968084 and rs7817 in gastric cancer patients were similar with the controls (OR 0.192, 95 % CI 0.513–2.769, P = 0.683 and OR 2.075, 95 % CI 0.744–5.792, P = 0.16, respectively). Patients with gastric cancer had a significantly higher frequency of rs3807213 C allele and rs3807213 C/C genotype than controls. (OR 4.028, 95 % CI 1.513–10.72, P = 0.004) (OR 3.759, 95 % CI 1.521–9.294, P = 0.003). This study suggests that the SNPs of IFRD1 rs7818 and rs6968084 have nothing to do with the gastric cancer susceptibility. The allele gene C and genotype C/C of rs3807213 SNP are involved in susceptibility to gastric cancer, but there were no relations when subgroup stratified all the three SNPs according to pathological stages.
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References
Kamangar F, Dores GM, Anderson WF. Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol. 2006;24(14):2137–50.
Katsha A, Soutto M, Sehdev V, Peng D, et al. Aurora kinase A promotes inflammation and tumorigenesis in mice and human gastric neoplasia. Gastroenterology. 2013;145(6):1312–22.
Lu W, Pan K, Zhang L, Lin D, et al. Genetic polymorphisms of interleukin (IL)-1B, IL-1RN, IL-8, IL-10 and tumor necrosis factor α and risk of gastric cancer in a Chinese population. Carcinogenesis. 2005;26(3):631–6.
Pohjanen V-M, Koivurova O-P, et al. Interleukin 6 gene polymorphism-174 is associated with the diffuse type gastric carcinoma. Genes Chromosom Cancer. 2013;52(10):976–82.
Bahrami H, Kamangar F. Tumour-necrosis factor-A polymorphisms and gastric cancer risk: a meta-analysis. Br J Cancer. 2008;98(8):1443–51.
Sharabash NM, Koblin R, Piccirillo J, et al. Novel IFRD1 (TIS7) expression patterns in human colon adenocarcinomas. Gastroenterology. 2011;140(5):S344.
Hector A, Kormann M, Rieber N, Mays L, et al. Expression and regulation of IFRD1 in neutrophils of cystic fibrosis patients. Pediatr Pulmonol. 2012;47:263.
Coussens LM, Werb Z. Inflammation and cancer. Nature. 2002;420(6917):860–70.
Zheng J. Toll-like receptors, chronic inflammation and cancer. Chin Bull Life Sci. 2009;19(1):15–20.
Xing PX, Xiao DJ, Hu AL, et al. Relationship between tumor necrosis factor-α and interleukin-6 gene polymorphism and susceptibility to gastric cancer. J Shandong Univ. (Health Sci). 2006;44:949–53.
Zhang Y, Zhang ZG, Qi FX, et al. Study on the association between interleukin-1 loci polymorphism and risk of gastric cancer. Chin J Dig Endosc. 2006;23(3):189–93.
Zhang J, Dou C, Song Y, et al. Polymorphisms of tumor necrosis factor-alpha are associated with increased susceptibility to gastric cancer: a meta-analysis. J Hum Genet. 2008;53(6):479–89.
Persson C, Canedo P, Machado JC, et al. Polymorphisms in inflammatory response genes and their association with gastric cancer: a HuGE systematic review and meta-analyses. Am J Epidemiol. 2011;1173(3):259–70.
Nong F, Zhou LY, Lin SR. The relationships between interleukin-1 gene polymorphism and gastric cancer in Beijing region. Chin J Dig. 2004;24(12):707–10.
Melo Barbosa HP, Martins LC, Dos Santos SE, et al. Interleukin-1 and TNF-alpha polymorphisms and Helicobacter pylori in a Brazilian Amazon population. World J Gastroenterol. 2009;15(12):1465–71.
Canavan C, Abrams KR, Mayberry J. Meta-analysis: colorectal and small bowel cancer risk in patients with Crohn’s disease. Aliment Pharmacol Ther. 2006;23(8):1097–104.
Wei XW, Chen JF. Progress in colitis associated colorectal cancer. Chin J Cancer Prev Treat. 2010;17(21):1795–8.
Lin CM, Wang GM, Jow GM, et al. Functional analysis of hepatitis B virus pre-s deletion variants associated with hepatocellular carcinoma. J Biomed Sci. 2012;19:17.
Meng XX. Precancerous lesion and gastric-related disease. Med J Commun. 2006;20(4):364–6.
Liang C, Fang ZQ, Guang DY, et al. Role of IFRD1 in hepatocarcinoma cells and regulation effects of several TCM therapeutic methods on its expression. World Sci Technol. 2010;12(5):723–8.
Buanne P, Incerti B, Guardavaccaro D, et al. Cloning of the human interferon-related developmental regulator (IFRD1) gene coding for the PC4 protein, a member of a novel family of developmentally regulated genes. Genomics. 1998;51(2):233–42.
Vietor I, Kurzbauer R, Brosch G, et al. TIS7 regulation of the beta-catenin/Tcf-4 target gene osteopontin (OPN) is histone deacetylase-dependent. J Biol Chem. 2005;280(48):39795–801.
Vietor I, Vadivelu SK, Wick N, et al. TIS7 interacts with the mammalian SIN3 histone deacetylase complex in epithelial cells. EMBO J. 2002;21(17):4621–31.
Cheon CW, Kim DH, Cho YH, et al. Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009;15(3):310–20.
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Xu, R., Peng, C., Xiao, S. et al. IFRD1 polymorphisms and gastric cancer risk in a Chinese population. Med Oncol 31, 135 (2014). https://doi.org/10.1007/s12032-014-0135-0
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DOI: https://doi.org/10.1007/s12032-014-0135-0