Neurocritical Care

, Volume 17, Issue 1, pp 139–145

A New Technology for Detecting Cerebral Blood Flow: A Comparative Study of Ultrasound Tagged NIRS and 133Xe-SPECT

Authors

  • Henrik W. Schytz
    • Danish Headache Center and Department of Neurology, Glostrup Hospital, Faculty of Health SciencesUniversity of Copenhagen
  • Song Guo
    • Danish Headache Center and Department of Neurology, Glostrup Hospital, Faculty of Health SciencesUniversity of Copenhagen
  • Lars T. Jensen
    • Clinical Physiology and Nuclear Medicine, Glostrup Hospital, Faculty of Health SciencesUniversity of Copenhagen
  • Moshe Kamar
    • Ornim Medical Ltd.
  • Asaph Nini
    • Ornim Medical Ltd.
  • Daryl R. Gress
    • Department of Neurology and NeurosurgeryUniversity of Virginia
    • Danish Headache Center and Department of Neurology, Glostrup Hospital, Faculty of Health SciencesUniversity of Copenhagen
Take Notice Technology

DOI: 10.1007/s12028-012-9720-2

Cite this article as:
Schytz, H.W., Guo, S., Jensen, L.T. et al. Neurocrit Care (2012) 17: 139. doi:10.1007/s12028-012-9720-2

Abstract

There is a need for real-time non-invasive, continuous monitoring of cerebral blood flow (CBF) during surgery, in intensive care units and clinical research. We investigated a new non-invasive hybrid technology employing ultrasound tagged near infrared spectroscopy (UT-NIRS) that may estimate changes in CBF using a cerebral blood flow index (CFI). Changes over time for UT-NIRS CFI and 133Xenon single photon emission computer tomography (133Xe-SPECT) CBF data were assessed in 10 healthy volunteers after an intravenous bolus of acetazolamide. UT-NIRS CFI was measured continuously and SPECT CBF was measured at baseline, 15 and 60 min after acetazolamide. We found significant changes over time in CFI by UT-NIRS and CBF by SPECT after acetazolamide (P ≤ 0.001). Post hoc tests showed a significant increase in CFI (P = 0.011) and SPECT CBF (P < 0.001) at 15 min after acetazolamide injection. There was a significant correlation between CFI and SPECT CBF values (r = 0.67 and P ≤ 0.033) at 15 min, but not at 60 min (P ≥ 0.777). UT-NIRS detected an increase in CFI following an acetazolamide bolus, which correlated with CBF measured with 133Xe-SPECT. This study demonstrates that UT-NIRS technology may be a promising new technique for non-invasive and real-time bedside CBF monitoring.

Keywords

Cerebral blood flowUltrasound tagged near infrared spectroscopy133Xenon single photon emission computer tomographyAcetazolamideMonitoring

Copyright information

© Springer Science+Business Media, LLC 2012