Neurocritical Care

, Volume 17, Issue 1, pp 139–145

A New Technology for Detecting Cerebral Blood Flow: A Comparative Study of Ultrasound Tagged NIRS and 133Xe-SPECT

  • Henrik W. Schytz
  • Song Guo
  • Lars T. Jensen
  • Moshe Kamar
  • Asaph Nini
  • Daryl R. Gress
  • Messoud Ashina
Take Notice Technology

DOI: 10.1007/s12028-012-9720-2

Cite this article as:
Schytz, H.W., Guo, S., Jensen, L.T. et al. Neurocrit Care (2012) 17: 139. doi:10.1007/s12028-012-9720-2

Abstract

There is a need for real-time non-invasive, continuous monitoring of cerebral blood flow (CBF) during surgery, in intensive care units and clinical research. We investigated a new non-invasive hybrid technology employing ultrasound tagged near infrared spectroscopy (UT-NIRS) that may estimate changes in CBF using a cerebral blood flow index (CFI). Changes over time for UT-NIRS CFI and 133Xenon single photon emission computer tomography (133Xe-SPECT) CBF data were assessed in 10 healthy volunteers after an intravenous bolus of acetazolamide. UT-NIRS CFI was measured continuously and SPECT CBF was measured at baseline, 15 and 60 min after acetazolamide. We found significant changes over time in CFI by UT-NIRS and CBF by SPECT after acetazolamide (P ≤ 0.001). Post hoc tests showed a significant increase in CFI (P = 0.011) and SPECT CBF (P < 0.001) at 15 min after acetazolamide injection. There was a significant correlation between CFI and SPECT CBF values (r = 0.67 and P ≤ 0.033) at 15 min, but not at 60 min (P ≥ 0.777). UT-NIRS detected an increase in CFI following an acetazolamide bolus, which correlated with CBF measured with 133Xe-SPECT. This study demonstrates that UT-NIRS technology may be a promising new technique for non-invasive and real-time bedside CBF monitoring.

Keywords

Cerebral blood flowUltrasound tagged near infrared spectroscopy133Xenon single photon emission computer tomographyAcetazolamideMonitoring

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Henrik W. Schytz
    • 1
  • Song Guo
    • 1
  • Lars T. Jensen
    • 2
  • Moshe Kamar
    • 3
  • Asaph Nini
    • 3
  • Daryl R. Gress
    • 4
  • Messoud Ashina
    • 1
  1. 1.Danish Headache Center and Department of Neurology, Glostrup Hospital, Faculty of Health SciencesUniversity of CopenhagenGlostrupDenmark
  2. 2.Clinical Physiology and Nuclear Medicine, Glostrup Hospital, Faculty of Health SciencesUniversity of CopenhagenGlostrupDenmark
  3. 3.Ornim Medical Ltd.LodIsrael
  4. 4.Department of Neurology and NeurosurgeryUniversity of VirginiaCharlottesvilleUSA