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mTOR Signaling in Parkinson’s Disease

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Abstract

As a key regulator of cell metabolism and survival, mechanistic target of rapamycin (mTOR) emerges as a novel therapeutic target for Parkinson’s disease (PD). A growing body of research indicates that restoring perturbed mTOR signaling in PD models can prevent neuronal cell death. Nevertheless, molecular mechanisms underlying mTOR-mediated effects in PD have not been fully understood yet. Here, we review recent progress in characterizing the association of mTOR signaling with PD risk factors and further discuss the potential roles of mTOR in PD.

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Acknowledgments

The authors gratefully acknowledge the financial support from the National Natural Science Foundation of China (Grant No. 11375213, 21390411) and Hundred Talents Program of the Chinese Academy of Sciences.

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Authors and Affiliations

  1. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Multi-disciplinary Research Division, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing, 100049, China

    Ai-ping Lan, Jun Chen, Yuliang Zhao, Zhifang Chai & Yi Hu

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  1. Ai-ping Lan
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  2. Jun Chen
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  3. Yuliang Zhao
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  4. Zhifang Chai
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  5. Yi Hu
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Correspondence to Yi Hu.

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Lan, Ap., Chen, J., Zhao, Y. et al. mTOR Signaling in Parkinson’s Disease. Neuromol Med 19, 1–10 (2017). https://doi.org/10.1007/s12017-016-8417-7

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