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Method of evaluation of process of red blood cell sedimentation based on photometry of droplet samples

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Abstract

The paper focuses on research aimed at creating and testing a new approach to evaluate the processes of aggregation and sedimentation of red blood cells for purpose of its use in clinical laboratory diagnostics. The proposed method is based on photometric analysis of blood sample formed as a sessile drop. The results of clinical approbation of this method are given in the paper. Analysis of the processes occurring in the sample in the form of sessile drop during the process of blood cells sedimentation is described. The results of experimental studies to evaluate the effect of the droplet sample focusing properties on light radiation transmittance are presented. It is shown that this method significantly reduces the sample volume and provides sufficiently high sensitivity to the studied processes.

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Authors and Affiliations

  1. Department of Industrial and Medical Electronics, Tomsk Polytechnic University, Lenin Avenue 30, Tomsk, Russian Federation, 634050

    Alexander Aristov & Ekaterina Nosova

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  1. Alexander Aristov
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  2. Ekaterina Nosova
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Correspondence to Ekaterina Nosova.

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Aristov, A., Nosova, E. Method of evaluation of process of red blood cell sedimentation based on photometry of droplet samples. Med Biol Eng Comput 55, 621–630 (2017). https://doi.org/10.1007/s11517-016-1542-5

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  • DOI: https://doi.org/10.1007/s11517-016-1542-5

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