Abstract
Background Cost-containment strategies are required to deal with rising drug expenditure, also in oncology. Drug wastage related to the preparation of chemotherapy drugs for patients is costly, but solutions exist for optimizing the use of unconsumed anticancer drugs. Objective Our pharmacy department makes use of a computerized drug storage bank, which records stability data and the amounts of unconsumed drugs available, and is connected to prescription software via an interface. We aimed to evaluate the real cost savings generated by this system. Method We assessed the cost savings achieved with this system, for 37 different anticancer drugs, over a 1-year period. French drug pricing and the amounts of drugs from the storage bank potentially re-used were assessed. Results The re-use of unconsumed anticancer drugs generated substantial cost savings, for nine drugs in particular: azacitidine, bevacizumab, bortezomib, cetuximab, docetaxel, liposomal doxorubicin, rituximab, topotecan and trastuzumab. Overall cost savings accounted for about 5 % of total anticancer drug expenditure at our hospital (€8.5 M). Conclusion In medical hematology-oncology, drug wastage reduction and a computerized physician order entry system could be applied in routine practice at centralized drug-processing units, with significant financial benefits.
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References
Meropol NJ, Schulman KA. Cost of cancer care: issues and implications. J Clin Oncol. 2007;25(2):180–6.
Lewden-Bernadac B, Courant-Menanteau M, Perrocheau G, Barbarot V, Thomare P. Outpatient chemotherapy and oncology network : onco Pays-de-la-Loire experiment. Bull Cancer. 2008;95(5):543–9.
Lievre A, Bachet JB, Le Corre D, Boige V, Landi B, Emile JF, et al. KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. Cancer Res. 2006;66(8):3992–5.
Romond EH, Perez EA, Bryant J, Suman VJ, Geyer CE Jr, Davidson NE, et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med. 2005;353(16):1673–84.
Fasola G, Aita M, Marini L, Follador A, Tosolini M, Mattioni L, et al. Drug waste minimisation and cost-containment in Medical Oncology: two-year results of a feasibility study. BMC Health Serv Res. 2008;8:70.
Gillerman RG, Browning RA. Drug use inefficiency: a hidden source of wasted health care dollars. Anesth Analg. 2000;91(4):921–4.
Nava-Ocampo AA, Alarcon-Almanza JM, Moyao-Garcia D, Ramirez-Mora JC, Salmeron J. Undocumented drug utilization and drug waste increase costs of pediatric anesthesia care. Fundam Clin Pharmacol. 2004;18(1):107–12.
Walker SE, Iazzetta J, De Angelis C, Gafni A. Chemotherapy waste reduction through shelf-life extension. Can J Hosp Pharm. 1994;47(1):15–23.
Winger BJ, Clements EA, Deyoung JL, O’Rourke TJ, Claypool DL, Vachon S, et al. Cost savings from dose rounding of biologic anticancer agents in adults. J Oncol Pharm Pract. 2011;17(3):246–51.
Bardin C, Astier A, Vulto A, Sewell G, Vigneron J, Trittler R, et al. Guidelines for the practical stability studies of anticancer drugs: a European consensus conference. Ann Pharm Fr. 2011;69(4):221–31.
Acknowledgments
We would like to thank the pharmacy of Tours University for their cooperation. We also thank Julie Sappa, of Alex Edelman and Associates, for assistance with the translation of this manuscript.
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Respaud, R., Tournamille, JF., Saintenoy, G. et al. Computer-assisted management of unconsumed drugs as a cost-containment strategy in oncology. Int J Clin Pharm 36, 892–895 (2014). https://doi.org/10.1007/s11096-014-9974-1
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DOI: https://doi.org/10.1007/s11096-014-9974-1