Journal of Neuro-Oncology

, Volume 106, Issue 1, pp 53–58

The genotoxic effect of radiofrequency waves on mouse brain

  • Emin Karaca
  • Burak Durmaz
  • Huseyin Altug
  • Teoman Yildiz
  • Candan Guducu
  • Melis Irgi
  • Mehtap Gulcihan Cinar Koksal
  • Ferda Ozkinay
  • Cumhur Gunduz
  • Ozgur Cogulu
Laboratory Investigation - Human/Animal Tissue

DOI: 10.1007/s11060-011-0644-z

Cite this article as:
Karaca, E., Durmaz, B., Altug, H. et al. J Neurooncol (2012) 106: 53. doi:10.1007/s11060-011-0644-z

Abstract

Concerns about the health effects of radiofrequency (RF) waves have been raised because of the gradual increase in usage of cell phones, and there are scientific questions and debates about the safety of those instruments in daily life. The aim of this study is to evaluate the genotoxic effects of RF waves in an experimental brain cell culture model. Brain cell cultures of the mice were exposed to 10.715 GHz with specific absorbtion rate (SAR) 0.725 W/kG signals for 6 h in 3 days at 25°C to check for the changes in the micronucleus (MNi) assay and in the expression of 11 proapoptotic and antiapoptotic genes. It was found that MNi rate increased 11-fold and STAT3 expression decreased 7-fold in the cell cultures which were exposed to RF. Cell phones which spread RF may damage DNA and change gene expression in brain cells.

Keywords

Radiofrequency Cell phone DNA Genotoxity 

Copyright information

© Springer Science+Business Media, LLC. 2011

Authors and Affiliations

  • Emin Karaca
    • 1
  • Burak Durmaz
    • 1
  • Huseyin Altug
    • 2
  • Teoman Yildiz
    • 3
  • Candan Guducu
    • 4
  • Melis Irgi
    • 4
  • Mehtap Gulcihan Cinar Koksal
    • 5
  • Ferda Ozkinay
    • 1
  • Cumhur Gunduz
    • 6
  • Ozgur Cogulu
    • 1
  1. 1.Department of Medical GeneticsEge University Faculty of MedicineIzmirTurkey
  2. 2.Department of Histology and EmbryologyEge University Faculty of MedicineIzmirTurkey
  3. 3.Department of PhysicsEge University Faculty of ScienceIzmirTurkey
  4. 4.High School of ScienceIzmirTurkey
  5. 5.Department of PharmacologyEge University Faculty of MedicineIzmirTurkey
  6. 6.Department of Medical BiologyEge University Faculty of MedicineIzmirTurkey