Abstract
Magnetic polymer particles have attracted large attention, due to their potential applications in biomedical field such as drug delivery, protein adsorption, magnetic resonance imaging and etc. A combinatorial method based on reversible addition fragmentation chain transfer (RAFT) polymerization and thiol-ene click chemistry was adopted to synthesize magnetic core-shell polymer hybrids. Well-defined poly (N-isopropylacrylamide) with trithiocarbonate moieties (PNIPAAm-CTA) was designed by RAFT polymerization and then was reduced to thiol-end polymers (PNIPAAm-SH). On the other hand, the magnetic particles (Fe3O4) were prepared by hydrothermal method, modified with silane coupling agent (KH-550) and acrylic acid to introduce vinyl group (−CH = CH2) onto the inorganic surface. Then the Fe3O4-g-PNIPAAm particles were synthesized by using thiol-ene click chemistry. The chemical composition, surface morphology, core-shell structure were characterized by a series of techniques such as Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), thermogravimetric analysis (TGA), X-ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM), dynamic light scattering (DLS) and vibrating sample magnetometer (VSM). The results showed that the as-synthesized composite iron oxide particles owned thermoresponsive behaviors and superparamagnetic properties. And, the superparamagnetic thermoresponsive particles with high magnetization might be potential ideal candidates for biomedical field.
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Acknowledgments
This work was supported by a grant from the National Natural Science Foundation of China (No.51172171), Science and technology support program Hubei province (No. 2015BAA085), Science and Technology Project of Wuhan (No. 20150601010 10032), Natural Science Foundation of Hubei Province (No. 2015CFB 551). Also thanks for equipments from Wuhan University of Technology Materials Research and Testing Center.
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Liu, R., Zhang, P. & Dai, H. Synthesis of magnetic particles with well-defined living polymeric chains via combination of RAFT polymerization and thiol-ene click chemistry. J Polym Res 23, 218 (2016). https://doi.org/10.1007/s10965-016-1113-3
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DOI: https://doi.org/10.1007/s10965-016-1113-3