Abstract
Unlike students in other engineering disciplines, undergraduates in biological engineering typically have limited opportunity to develop design competencies, and even fewer chances to implement their designed projects. The international Genetically Engineered Machines (iGEM) competition is a student Synthetic Biology competition that, in 2009, included 110 teams from across Asia, Europe, Latin America, and the US. Working at their own schools over the summer, the students use a kit of biological parts from the Registry of Standard Biological Parts, as well as new parts of their own design, to build biological systems that operate in living cells. Two years of survey data collected from undergraduates after their iGEM experiences in 2007 and 2008 suggest that both learning and identity as a biological engineer increase as a result of iGEM.
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Baumgardner J, Acker K, Adefuye O, Crowley ST, DeLoache W, Dickson JO et al (2009) Solving a Hamiltonian path problem with a bacterial computer. J Biol Eng 3(11). http://www.jbioleng.org/content/3/1/11/abstract
Brown J (2007) The iGEM competition: building with biology. IET Synth Biol 1(1–2):3–6. doi:10.1049/iet-stb:20079020
Campbell AM (2005) Meeting report: synthetic biology jamboree for undergraduates. Cell Biol Educ 4(1):19–23. http://www.lifescied.org/cgi/content/full/4/1/19
Dori YJ (2007) Educational reform at MIT: advancing and evaluating technology-based projects on- and off-campus. J Sci Educ Technol 16(4):279–281. http://springerlink.com/content/h34h5879256x18p2/
Gardner TS, Cantor CR, Collins JJ (2000) Construction of a genetic toggle switch in Escherichia coli. Nature 403(6767):339–342. http://www.nature.com/nature/journal/v403/n6767/full/403339a0.html
Haynes KA, Broderick ML, Brown AD, Butner TL, Dickson JO, Harden WL et al (2008) Engineering bacteria to solve the burnt pancake problem. J Biol Eng 2(8) http://www.jbioleng.org/content/2/1/8/abstract
Knight T (2003) Idempotent vector design for standard assembly of biobricks. http://hdl.handle.net/1721.1/21168
Kuldell N (2007) Authentic teaching and learning through synthetic biology. J Biol Eng 1(8). http://www.jbioleng.org/content/1/1/8/abstract
Levskaya A, Chevalier AA, Tabor JJ, Simpson ZB, Lavery LA, Levy M et al (2005) Synthetic biology: engineering Escherichia coli to see light. Nature 438:441–442. http://www.nature.com/nature/journal/v438/n7067/full/nature04405.html
Lohmueller J, Neretti N, Hickey B, Kaka A, Gao A, Lemon J et al (2007) Progress toward construction and modelling of a tri-stable toggle switch in E. coli. IET Synth Biol 1(1–2):25–28. doi:0.1049/iet-stb:20070001
Mitchell R, Kuldell N (2007) iGEM post-jamboree survey. http://hdl.handle.net/1721.1/44631
Mitchell R, Kuldell N (2008) iGEM post-jamboree survey. http://hdl.handle.net/1721.1/44632
Moore GT, Block SD, Style CB, Mitchell R (1994) The influence of the new pathway curriculum on Harvard medical students. Acad Med 69(12):983–989. http://journals.lww.com/academicmedicine/Abstract/1994/12000/The_influence_of_the_New_Pathway_curriculum_on.17.aspx
Russell SH (2008) Undergraduate research opportunities: facilitating and encouraging the transition from student to scientist. In: Taraban R, Blanton RL (eds) Creating effective undergraduate research programs in science: the transformation from student to scientist. Teachers College Press, New York, NY, pp 53–80
Tabor JJ, Salis HM, Simpson ZB, Chevalier AA, Levskaya A, Marcotte EM et al (2009) A synthetic genetic edge detection program. Cell 137(7):1272–1281. http://www.cell.com/abstract/S0092-8674%2809%2900509-1
Terzer M, Jovanovic M, Choutko A, Nikolayeva O, Korn A, Brockhoff D et al (2007) Design of a biological half adder. IET Synth Biol 1(1.2):53–58. http://ieeexplore.ieee.org/xpl/freeabs_all.jsp?&arnumber=4290620
Thomas JW (2000) A review of research on project-based learning. autodesk foundation review of PBL http://web.archive.org/web/20030812124529/www.k12reform.org/foundation/pbl/research/
Acknowledgments
We thank all the students and faculty associated with iGEM who participated in these surveys and so candidly described their experiences. We also thank R. Rettburg and M. Lizarazo for distribution of the survey to iGEM participants. We thank Malcolm Campbell and Fred Winston for improving this manuscript. Funding for the survey distribution and analysis was from the NSF-funded Synthetic Biology Engineering Research Center (SynBERC).
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Mitchell, R., Dori, Y.J. & Kuldell, N.H. Experiential Engineering Through iGEM—An Undergraduate Summer Competition in Synthetic Biology. J Sci Educ Technol 20, 156–160 (2011). https://doi.org/10.1007/s10956-010-9242-7
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DOI: https://doi.org/10.1007/s10956-010-9242-7