Update on the use of dehydroepiandrosterone supplementation among women with diminished ovarian function
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We assessed the role of DHEA supplementation on pregnancy rates in women with diminished ovarian function.
This is a case control study of 190 women with diminished ovarian function. The study group includes 89 patients who used supplementation with 75 mg daily of oral, micronized DHEA for up to 4 months prior to entry into in vitro fertilization (IVF). The control group is composed of 101 couples who received infertility treatment, but did not use DHEA. The primary outcome was clinical pregnancy after the patient’s initial visit. We developed a Cox proportional hazards model to compare the proportional hazards of pregnancy among women using DHEA with the controls group.
Cumulative clinical pregnancy rates were significantly higher in the study group (25 pregnancies; 28.4% vs. 11 pregnancies; 11.9%; relative hazard of pregnancy in study group (HR 3.8; 95% CI 1.2–11.8; p < 0.05).
DHEA treatment resulted in significantly higher cumulative pregnancy rates. These data support a beneficial effect of DHEA supplementation among women with diminished ovarian function.
- Update on the use of dehydroepiandrosterone supplementation among women with diminished ovarian function
Journal of Assisted Reproduction and Genetics
Volume 24, Issue 12 , pp 629-634
- Cover Date
- Print ISSN
- Online ISSN
- Springer US
- Additional Links
- Diminished ovarian reserve
- In vitro fertilization, Pregnancy rates
- Life table analysis
- Industry Sectors
- Author Affiliations
- 1. Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Bronx, NY, USA
- 2. Department of Obstetrics and Gynecology & Women’s Health, Albert Einstein College of Medicine, Bronx, NY, USA
- 5. The Center for Human Reproduction (CHR), 21 East 69th Street, New York, NY, 10021, USA
- 6. The Foundation for Reproductive Medicine, Chicago, IL, USA
- 3. Department of Obstetrics and Gynecology, Lenox Hill Hospital, Manhattan, NY, USA
- 4. Department of Obstetric and Gynecology, Yale University School of Medicine, New Haven, CT, USA