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Novel and Efficient Heterogeneous 4-Methylbenzenesulfonic Acid-Based Ionic Liquid Supported on Silica Gel for Greener Fischer Indole Synthesis

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Abstract

In this work, a functionalizing active species 4-methylbenzenesulfonic acid-based IL on silica gel (IL-SO3H-SiO2) has been prepared, and characterized by FT-IR, XRD, TGA, SEM and EDX spectra. Then, IL-SO3H-SiO2 was utilized as an efficient and heterogeneous catalyst for the synthesis of indoles via the one-pot Fischer reaction of phenyl hydrazines with ketones or aldehydes at room temperature. The heterogeneous catalyst could be recovered easily by filtration and reused many times without significant loss of its catalytic activity.

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Acknowledgments

The authors would like to acknowledge financial support provided by the National Natural Science Foundation of China (No. 21506115) and the Natural Science Foundation of Jiangsu Province (No. BK20140460) for carrying out this research.

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Authors and Affiliations

  1. College of Materials and Chemical Engineering, China Three Gorges University, Yichang, 443002, People’s Republic of China

    Yu-Lin Hu & Dong-Sheng Li

  2. Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials, China Three Gorges University, Yichang, 443002, People’s Republic of China

    Yu-Lin Hu & Dong-Sheng Li

  3. College of Chemistry and Chemical Engineering, Yancheng Teachers University, Yancheng, 224002, People’s Republic of China

    Dong Fang

Authors
  1. Yu-Lin Hu
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  2. Dong Fang
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  3. Dong-Sheng Li
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Correspondence to Yu-Lin Hu or Dong-Sheng Li.

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Hu, YL., Fang, D. & Li, DS. Novel and Efficient Heterogeneous 4-Methylbenzenesulfonic Acid-Based Ionic Liquid Supported on Silica Gel for Greener Fischer Indole Synthesis. Catal Lett 146, 968–976 (2016). https://doi.org/10.1007/s10562-016-1721-x

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  • DOI: https://doi.org/10.1007/s10562-016-1721-x

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