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Prevalence of women with early-stage breast cancer receiving active management using electronic health records from oncology clinics in the United States

  • Epidemiology
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Abstract

The purpose of this study was to estimate the prevalence of women receiving treatment or active surveillance for stage I–III breast cancer in the United States from 2009 to 2012, stratified by patient age and tumor characteristics. In each study year, electronic medical records were used to identify women aged ≥18 years with stage I–III breast cancer and treated or under active surveillance (≥4 visits) at an oncology clinic that contributes data to the Oncology Services Comprehensive Electronic Records database. Prevalence was projected to the national level overall and within strata (by tumor characteristics, year of breast cancer diagnosis, and age). We identified 5,219 female breast cancer patients (18 % <age 50; 58 % <age 65) representing 787,082 (95 % CI 778,012–796,153) women in the US in 2012. At diagnosis, 44 % had stage I, 42 % stage II, and 14 % stage III disease; 69 % had estrogen receptor (ER) and progesterone receptor (PR) expression-positive tumors; 19 % were ER- and PR-negative; and 14 % had triple-negative phenotype (ER-, PR-, and HER2-negative). Overall 56 % of patients received treatment in 2012, 22 % chemotherapy, 8 % biologic therapy, and 36 % endocrine therapy. Treatment prevalence was higher among younger patients and at more advanced disease stages. Approximately half of women with ER-negative, PR-positive, HER2-negative, or triple-negative tumors received chemotherapy. As a conclusion, in 2012, approximately 800,000 women in the US were under treatment or active surveillance for early-stage breast cancer. Treatment prevalence differed by patient age, disease stage, and tumor histology.

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Acknowledgements

This work was supported by Amgen, Inc.

Conflict of interest

RK Hernandez and A Liede are employees and stockholders of Amgen Inc. SW Wade is a partner in Wade Outcomes Research and Consulting and has received consulting fees from Amgen Inc. D Quach, M Pirolli, and J Quigley are employed by IMS Health which has received consulting fees from Amgen Inc. SA Narod is affiliated with the Women’s College Research Institute.

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Authors and Affiliations

  1. Center for Observational Research, Amgen Inc., Thousand Oaks, CA, USA

    Rohini K. Hernandez

  2. IMS Health, Plymouth Meeting, PA, USA

    David Quach, Melissa Pirolli & Jane Quigley

  3. Wade Outcomes Research and Consulting, Salt Lake City, UT, USA

    Sally W. Wade

  4. Women’s College Research Institute, 790 Bay Street, Toronto, ON, Canada

    Steven A. Narod

  5. Center for Observational Research, Amgen Inc., 1120 Veterans Blvd, ASF5, South San Francisco, CA, 94080, USA

    Alexander Liede

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  1. Rohini K. Hernandez
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  2. David Quach
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  3. Sally W. Wade
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  4. Melissa Pirolli
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  5. Jane Quigley
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  6. Steven A. Narod
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  7. Alexander Liede
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Correspondence to Alexander Liede.

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Hernandez, R.K., Quach, D., Wade, S.W. et al. Prevalence of women with early-stage breast cancer receiving active management using electronic health records from oncology clinics in the United States. Breast Cancer Res Treat 146, 637–646 (2014). https://doi.org/10.1007/s10549-014-3052-1

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  • DOI: https://doi.org/10.1007/s10549-014-3052-1

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