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Effect of 24-h continuous rotigotine treatment on stationary and non-stationary locomotion in de novo patients with Parkinson disease in an open-label uncontrolled study

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Abstract

The aim of this study was to investigate the effect of a rotigotine transdermal patch on stationary and non-stationary locomotion in de novo Parkinson disease (PD) patients in an open-label uncontrolled study. A 3-D gait analysis system was used to investigate four different locomotor tasks: steady-state linear walking, gait initiation, gait termination and 180°-turning. A series of gait variables were measured for each locomotor task. PD patients who received rotigotine treatment (4–8 mg) displayed: (1) increased step length, gait speed, cadence and arm oscillations, and reduced double support duration and step asymmetry during steady-state linear gait; (2) increased initial step length during gait initiation; (3) increased final step length and gait speed, and decreased stability index during gait termination; (4) decreased duration of turning and head–pelvis delays during 180°-turning. The main finding that emerges from the present study is that the dopamine agonist rotigotine can improve various aspects of gait in de novo PD patients.

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Abbreviations

PD:

Parkinson disease

DA:

Dopamine antagonists

CoP:

Center of pressure

CoM:

Center of mass

GI:

Gait initiation

GT:

Gait termination

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Correspondence to Mariano Serrao.

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Conflicts of interest

We report the following consultancy for Alfonso Fasano, Stock Ownership in medically-related fields: none; Consultancies: UCB pharma, Medtronic, Boston Scientific, Abbvie; Advisory Boards: Abbvie; Partnerships: none; Honoraria: UCB pharma, Medtronic, Boston Scientific, Abbvie; Grants: University of Toronto, Michael J. Fox Foundation; Intellectual Property Rights: none; Expert Testimony: none; Employment: none; Contracts: none; Royalties: none; Other: none; The other authors declare any financial or other relationships that might lead to a conflict of interest.

The other authors declare any financial or other relationships that might lead to a conflict of interest.

Ethical standard

Informed consent was obtained from all the participants in the study, which was approved by the local institutional review board. All experimental procedures were in accord with the Declaration of Helsinki.

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Serrao, M., Ranavolo, A., Conte, C. et al. Effect of 24-h continuous rotigotine treatment on stationary and non-stationary locomotion in de novo patients with Parkinson disease in an open-label uncontrolled study. J Neurol 262, 2539–2547 (2015). https://doi.org/10.1007/s00415-015-7883-4

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  • DOI: https://doi.org/10.1007/s00415-015-7883-4

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