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Echocardiographic findings in patients with spontaneous CSF leak

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Abstract

The presence of cardiovascular abnormalities in patients with spontaneous cerebrospinal fluid (CSF) leaks are not well-documented in the literature, as cardiovascular evaluation is not generally pursued if a patient does not exhibit additional clinical features suggesting an inherited connective tissue disorder. We aimed to assess this association, enrolling a consecutive group of 50 patients referred for spinal CSF leak consultation. Through echocardiographic evaluation and detailed medical history, we estimate that up to 20 % of patients presenting with a spontaneous CSF leak may have some type of cardiovascular abnormality. Further, the increase in prevalence of aortic dilatation in our cohort was statistically significant in comparison to the estimated population prevalence. This supports a clinical basis for echocardiographic screening of these individuals for cardiovascular manifestations that may have otherwise gone unnoticed or evolved into a more severe manifestation.

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Acknowledgments

The authors bear full responsibility for the content of this publication.

Conflicts of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.

Ethical standard

All human studies have been approved by the appropriate ethics committee and have therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

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Authors and Affiliations

  1. Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

    Allen L. Pimienta

  2. Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA

    David L. Rimoin & Mitchel Pariani

  3. Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA

    Wouter I. Schievink

  4. The Raphael Recanati Genetics Institute, Rabin Medical Center, Petach-Tikva, Israel

    Eyal Reinstein

Authors
  1. Allen L. Pimienta
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  2. David L. Rimoin
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  3. Mitchel Pariani
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  4. Wouter I. Schievink
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  5. Eyal Reinstein
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Corresponding author

Correspondence to Eyal Reinstein.

Additional information

David L. Rimoin: Deceased.

Appendix

Appendix

$$Z = \frac{(p1 - p2)}{{\sqrt {p(1 - p)(\frac{1}{n1} + \frac{1}{n2})} }}$$
$$Z = \frac{0.12 - 0.046}{{\sqrt {0.0475(1 - 0.0475)(\frac{1}{50} + \frac{1}{2451})} }} = \, 2.44, \, p \, = \, 0.01468$$

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Pimienta, A.L., Rimoin, D.L., Pariani, M. et al. Echocardiographic findings in patients with spontaneous CSF leak. J Neurol 261, 1957–1960 (2014). https://doi.org/10.1007/s00415-014-7438-0

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  • DOI: https://doi.org/10.1007/s00415-014-7438-0

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