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Maternal serum homocysteine and uterine artery Doppler as predictors of preeclampsia and poor placentation

  • Maternal-Fetal Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

An Editorial Expression of Concern to this article was published on 15 April 2024

An Editorial Expression of Concern to this article was published on 19 March 2024

This article has been updated

Abstract

Purpose

The aim of this study was to evaluate the role of maternal serum total Homocysteine (tHcy) and uterine artery (Ut-A) Doppler as predictors of preeclampsia (PE), intrauterine growth restriction (IUGR), and other complications related to poor placentation.

Patients and methods

A prospective cohort study was conducted on 500 women with spontaneous pregnancies. tHcy was measured at 15–19 weeks, and then, Ut-A Doppler was performed at 18–22 weeks of pregnancy.

Results

453 pregnant women completed the follow-up of the study. The tHcy and Ut-A resistance index were significantly higher in women who developed PE, IUGR, and other complications when compared to controls (tHcy: 7.033 ± 2.744, 6.321 ± 3.645, and 6.602 ± 2.469 vs 4.701 ± 2.082 μmol/L, respectively, p value <0.001 and Ut-A resistance index: 0.587 ± 0.072, 0.587 ± 0.053, and 0.597 ± 0.069 vs 0.524 ± 0.025, respectively, p value <0.001). The use of both tHcy assessment and Ut-A Doppler improved the sensitivity of prediction of PE relative to the use of each one alone (85.2 relative to 73.33 and 60%, respectively).

Conclusion

The use of elevated homocysteine and uterine artery Doppler screening are valuable in prediction of preeclampsia, IUGR, and poor placentation disorders.

ClincalTrial.gov ID

NCT02854501.

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Author information

Authors and Affiliations

  1. Obstetrics and Gynecology Department, Cairo University, 135 King Faisal St. Haram, Giza, 12151, Egypt

    Ahmed M. Maged, Hany Saad, Hadeer Meshaal, Emad Salah, Suzy Abdelaziz & Eman Omran

  2. Department of Obstetrics and Gynecology, Faculty of Medicine, Fayoum University, Fayoum, Egypt

    Wesam S. Deeb

  3. Department of Obstetrics and Gynecology, Faculty of Medicine, BeniSuef University, Beni Suef, Egypt

    Maha Katta

Authors
  1. Ahmed M. Maged
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  2. Hany Saad
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  3. Hadeer Meshaal
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  4. Emad Salah
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  5. Suzy Abdelaziz
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  6. Eman Omran
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  7. Wesam S. Deeb
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  8. Maha Katta
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Contributions

AMM: project development, data collection, and manuscript writing; HS: data collection; HM: data collection; ES: data collection; SA: manuscript writing and data collection; EO: data collection, data analysis, and manuscript writing; WD: manuscript writing; MK: manuscript writing.

Corresponding author

Correspondence to Ahmed M. Maged.

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Ethical standards

All procedures performed were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments. Informed consent was obtained from all individual participants included in the study.

Conflict of interest

The author reports no conflicts of interest in this work.

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Maged, A.M., Saad, H., Meshaal, H. et al. Maternal serum homocysteine and uterine artery Doppler as predictors of preeclampsia and poor placentation. Arch Gynecol Obstet 296, 475–482 (2017). https://doi.org/10.1007/s00404-017-4457-y

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  • DOI: https://doi.org/10.1007/s00404-017-4457-y

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