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NIR- and UV-dual responsive amphiphilic copolymer micelles with light-dissociable PAG-side groups

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Abstract

Amphiphilic random copolymer micelle of P(NVP-co-NHPM) that responds to both UV and NIR light was designed and investigated. N-hydroxyphthalimide methacrylate—bearing a photoacid generator functional group was synthesized and used to construct the hydrophobic segment of P(NVP-co-NHPM); the N–O bond can be photocleaved when exposing the polymer aqueous solution to 310 nm UV light irradiation, inducing the micellar dissociation and delivery of loaded substances. Dynamic light scattering (DLS), atomic force microscope (AFM), and transmission electron microscopy (TEM) were used to characterize the micellar dissociation and controlled release processes. Moreover, the upconverting nanoparticles (NaLuF4:Gd/Yb/Tm) that can effectively absorb NIR light and convert it into visible and UV light were coloaded into polymer micelles to activate the micellar dissociation and the delivery of loaded cargoes via 980 nm NIR light.

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Acknowledgements

This work is supported by the Nature Science Foundation of China (NSFC 21374056), the Program for Changjiang Scholars and Innovative Research Team in University (IRT 14R33), the Fundamental Research Funds for the Central Universities (GK201603038, GK201601005), Shaanxi Innovative Research Team for Key Science and Technology (2013KCT-17), and the One Hundred Plan of Shaanxi Province.

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Authors and Affiliations

  1. Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education. School of Chemistry & Chemical Engineering, Shaanxi Normal University, Xi’an, Shaanxi, 710062, China

    Youpeng Wang, Guo Li, Ruidong Cheng, Xuan Zhang & Jinqiang Jiang

  2. Department of Petrochemical Engineering, Lanzhou Petrochemical College of Vocational Technology, Lanzhou, Gansu, 730060, China

    Youpeng Wang

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  1. Youpeng Wang
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  2. Guo Li
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  3. Ruidong Cheng
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  4. Xuan Zhang
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  5. Jinqiang Jiang
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Correspondence to Guo Li or Jinqiang Jiang.

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Wang, Y., Li, G., Cheng, R. et al. NIR- and UV-dual responsive amphiphilic copolymer micelles with light-dissociable PAG-side groups. Colloid Polym Sci 295, 371–378 (2017). https://doi.org/10.1007/s00396-017-4013-0

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  • DOI: https://doi.org/10.1007/s00396-017-4013-0

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