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In situ preparation of gold nanospheres in bead composed of alginate/poly(N-isopropylacrylamide-co-dimethyl aminoethyl methacrylate) and photothermal controlled release

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Abstract

Near-infrared (NIR)-responsive beads were developed by reducing gold ions electrostatically captured in the bead matrix composed of alginate and poly(N-isopropylacrylamide-co-dimethyl aminoethyl methacrylate) (PNIPAM-DMAEMA). PNIPAM-DMAEMAs (95/5 and 85/15, molar ratio) were included as a thermo-responsive polymer. The beads were prepared by dropping mixture solution of alginate/PNIPAM-DMAEMA (0.6 % (w/v)/2.4 % (w/v)) into gold ions solution (100 mM). The gold ions in the bead matrix could be converted to gold nanosphere (10–13 nm in diameter) using sodium citrate as a reducing agent. The SEM-EDS revealed that gold nanospheres were dispersed in the bead matrix. The content of gold nanosphere in alginate/PNIPAM-DMAEMA (95/5) bead and PNIPAM-DMAEMA (85/15) bead, evaluated spectrophotometrically, was 3.19 and 0.91 %, respectively. The bead suspensions (1 %, w/v) were readily heated over 40 °C in 5 min upon NIR (808 nm, 2 W) irradiation. The release of FITC-dextran from PNIPAM-DMAEMA beads was significantly promoted by the irradiation. Due to the heat generated by the surface plasmon resonance of the gold nanospheres, the thermo-responsive polymer would undergo a thermal contraction and the pores of the bead matrix might be widened, leading to a facilitated release.

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Acknowledgments

This research was supported by the Technological Innovation R&D Program (S2127757) funded by Small and Medium Business Administration (SMBA, Korea).

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  1. Department of Medical Biomaterials Engineering, School of Medical Science and Institute of Bioscience and Biotechnology, Kangwon National University, 192-1, Hyoja 2 dong, Chunchon, Kangwon-do, 200-701, Republic of Korea

    Hee Jin Seo & Jin-Chul Kim

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  1. Hee Jin Seo
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  2. Jin-Chul Kim
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Correspondence to Jin-Chul Kim.

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Seo, H.J., Kim, JC. In situ preparation of gold nanospheres in bead composed of alginate/poly(N-isopropylacrylamide-co-dimethyl aminoethyl methacrylate) and photothermal controlled release. Colloid Polym Sci 293, 1425–1435 (2015). https://doi.org/10.1007/s00396-015-3524-9

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  • DOI: https://doi.org/10.1007/s00396-015-3524-9

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