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Association of macroscopic gut inflammation with disease activity, functional status and quality of life in ankylosing spondylitis

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Abstract

The aim of this cross-sectional study was to evaluate the frequency of intestinal inflammation and its association with disease activity, functional status and quality of life in patients with ankylosing spondylitis (AS). A total of 25 patients with AS had undergone ileocolonoscopy and concomitant histological study. Clinical and demographical parameters, BASDAI, BASFI, and SF-36 scores were compared between patients with and without macroscopic gut inflammation (MGI). Colonoscopic study revealed MGI in 9 patients and macroscopically normal gut mucosa in 16 patients. On histological examination, of 25 patients 20 had gut inflammation, mostly in ileum. BASDAI score was higher (P < 0.05), SF-36 pain and physical scores, and chest expansion measurement were lower (P = 0.00, P = 0.01, P = 0.01), duration of morning stiffness was longer (P = 0.01) in patients with MGI. Serum C-reactive protein, erytrocyte sedimentation rate levels were similar between groups (P > 0.05). There is high prevalence of histological gut inflammation in AS patients. More active disease should suggest gut inflammation in AS patients.

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Authors and Affiliations

  1. Ataturk Training and Research Hospital, Izmir, Turkey

    Gulen Hascelik, Bengi Oz, Nese Olmez, Asuman Memis, Gazi Yoruk, Belkıs Unsal & Nese Ekinci

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  1. Gulen Hascelik
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  2. Bengi Oz
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  3. Nese Olmez
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  4. Asuman Memis
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  5. Gazi Yoruk
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  6. Belkıs Unsal
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  7. Nese Ekinci
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Correspondence to Bengi Oz.

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Hascelik, G., Oz, B., Olmez, N. et al. Association of macroscopic gut inflammation with disease activity, functional status and quality of life in ankylosing spondylitis. Rheumatol Int 29, 755–758 (2009). https://doi.org/10.1007/s00296-008-0766-6

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  • DOI: https://doi.org/10.1007/s00296-008-0766-6

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