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Collagen-based hydrogel films as drug-delivery devices with antimicrobial properties

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Abstract

Collagen (coll)-containing hydrogel films were prepared by mixing degraded collagen with monomers such as acrylamide (AAm), and 2-hydroxy ethylmethacrylate (HEMA) before the polymerization/cross-linking of composites as p(coll-co-AAm), and p(coll-co-HEMA), respectively. These materials were used as drug-delivery devices for potential wound dressing materials by loading and releasing of model drugs such as gallic acid (GA) and naproxen (NP). A linear release profile was obtained up to 32-h release from GA-loaded p(coll-co-AAm) interpenetrating polymeric networks films, and 36-h linear release profile of NP for p(coll-co-HEMA). Furthermore, metal nanoparticles such as Ag and Cu prepared within these hydrogel films offered antimicrobial characteristic against known common bacteria such as Escherichia coli, Bacillus subtilis, and Staphylococcus aureus.

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Authors and Affiliations

  1. Department of Leather Engineering, Engineering Faculty, Ege University, Izmir, Turkey

    Mehtap Sahiner & Behzat O. Bitlisli

  2. Department of Chemistry, Van Yuzuncu Yıl University, Van, Turkey

    Duygu Alpaslan

Authors
  1. Mehtap Sahiner
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  2. Duygu Alpaslan
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  3. Behzat O. Bitlisli
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Correspondence to Mehtap Sahiner.

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Sahiner, M., Alpaslan, D. & Bitlisli, B.O. Collagen-based hydrogel films as drug-delivery devices with antimicrobial properties. Polym. Bull. 71, 3017–3033 (2014). https://doi.org/10.1007/s00289-014-1235-x

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  • DOI: https://doi.org/10.1007/s00289-014-1235-x

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