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Reply: Methotrexate neurotoxicity due to drug interactions: an inadequate folinic acid effect

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References

  1. Forster VJ, van Delft FW, Baird SF, Mair S, Skinner R, Halsey C (2016) Drug interactions may be important risk factors for methotrexate neurotoxicity, particularly in pediatric leukemia patients. Cancer Chemother Pharmacol 78(5):1093–1096

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Lobel U, Trah J, Escherich G (2015) Severe neurotoxicity following intrathecal methotrexate with nitrous oxide sedation in a child with acute lymphoblastic leukemia. Pediatr Blood Cancer 62(3):539–541

    Article  CAS  PubMed  Google Scholar 

  3. Krull KR, Cheung YT, Liu W et al (2016) Chemotherapy pharmacodynamics and neuroimaging and neurocognitive outcomes in long-term survivors of childhood acute lymphoblastic leukemia. J Clin Oncol 34(22):2644–2653

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Cohen IJ (2014) Inadequate folinic acid rescue after methotrexate causing neurocognitive and neuroradiological central nervous system late effects in children with acute lymphatic leukemia. J Pediatr Hematol Oncol 36(6):501

    Article  PubMed  Google Scholar 

  5. Cohen IJ (2013) Challenging the clinical relevance of folinic acid over rescue after high dose methotrexate (HDMTX). Med Hypotheses 81(5):942–947

    Article  CAS  PubMed  Google Scholar 

  6. Skarby TV, Anderson H, Heldrup J et al (2006) High leucovorin doses during high-dose methotrexate treatment may reduce the cure rate in childhood acute lymphoblastic leukemia. Leukemia 20(11):1955–1962

    Article  PubMed  Google Scholar 

  7. Borsi JD, Sagen E, Romslo I, Moe PJ (1990) Rescue after intermediate and high-dose methotrexate: background, rationale, and current practice. Pediatr Hematol Oncol 7(4):347–363

    Article  CAS  PubMed  Google Scholar 

  8. Eger EI 2nd (1985) Nitrous oxide/N2O. Elsevier, New York

    Google Scholar 

  9. Cole PD, Beckwith KA, Vijayanathan V, Roychowdhury S, Smith AK, Kamen BA (2009) Folate homeostasis in cerebrospinal fluid during therapy for acute lymphoblastic leukemia. Pediatr Neurol 40(1):34–41

    Article  PubMed  Google Scholar 

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Correspondence to Victoria J. Forster.

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Forster, V.J., van Delft, F.W., Baird, S.F. et al. Reply: Methotrexate neurotoxicity due to drug interactions: an inadequate folinic acid effect. Cancer Chemother Pharmacol 79, 841–842 (2017). https://doi.org/10.1007/s00280-017-3270-4

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  • DOI: https://doi.org/10.1007/s00280-017-3270-4

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