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Measuring the actual I-131 thyroid uptake curve with a collar detector system: a feasibility study

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Abstract

Radionuclide therapy using I-131 is commonly used for the treatment of benign thyroid diseases. The therapeutic dose to be administered is calculated based on the type of disease, the volume of the thyroid, and the measured uptake percentage. This methodology assumes a similar biological half-life of iodine, whereas in reality a large variation in biological half-life is observed. More knowledge about the actual biological half-life of iodine for individual patients will improve the quantification of the delivered radiation dose during radioiodine therapy and could aid the evaluation of the success of the therapy. In this feasibility study we used a novel measurement device [Collar Therapy Indicator (CoTI)] to measure the uptake curve of patients undergoing I-131 radioiodine therapy. The CoTI device is a light-weight wearable device that contains two independent gamma radiation detectors that are placed in a collar. By comparing results of thyroid uptake measurements with results obtained with a gamma camera, the precision of the system is demonstrated. Additionally, for three patients the uptake curve is measured during 48 h of admission in the hospital. The presented results demonstrate the feasibility of the new measurement device to measure the uptake curve during radioiodine therapy.

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Acknowledgments

The authors acknowledge AG Medical for supplying the CoTI device for this study.

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Authors and Affiliations

  1. Department of Medical Physics, St. Antonius Hospital, Nieuwegein, The Netherlands

    Peter Brinks, Koen Van Gils, Dennis Dieckens & Jan B. A. Habraken

  2. Department of Nuclear Medicine, St. Antonius Hospital, Nieuwegein, The Netherlands

    Ellen Kranenborg & Jules Lavalaye

Authors
  1. Peter Brinks
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  2. Koen Van Gils
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  3. Ellen Kranenborg
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  4. Jules Lavalaye
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  5. Dennis Dieckens
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  6. Jan B. A. Habraken
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Corresponding author

Correspondence to Peter Brinks.

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Informed consent was obtained from all individual participants in this study. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Brinks, P., Van Gils, K., Kranenborg, E. et al. Measuring the actual I-131 thyroid uptake curve with a collar detector system: a feasibility study. Eur J Nucl Med Mol Imaging 44, 935–940 (2017). https://doi.org/10.1007/s00259-016-3595-y

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  • DOI: https://doi.org/10.1007/s00259-016-3595-y

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