Detection rate of PET/CT in patients with biochemical relapse of prostate cancer using [68Ga]PSMA I&T and comparison with published data of [68Ga]PSMA HBED-CC

  • Christoph Berliner
  • Milena Tienken
  • Thorsten Frenzel
  • Yuske Kobayashi
  • Annabelle Helberg
  • Uve Kirchner
  • Susanne Klutmann
  • Dirk Beyersdorff
  • Lars Budäus
  • Hans-Jürgen Wester
  • Janos Mester
  • Peter Bannas
Original Article

DOI: 10.1007/s00259-016-3572-5

Cite this article as:
Berliner, C., Tienken, M., Frenzel, T. et al. Eur J Nucl Med Mol Imaging (2017) 44: 670. doi:10.1007/s00259-016-3572-5

Abstract

Purpose

To determine the detection rate of PET/CT in biochemical relapse of prostate cancer using [68Ga]PSMA I&T and to compare it with published detection rates of [68Ga]PSMA HBED-CC.

Methods

We performed a retrospective analysis in 83 consecutive patients with documented biochemical relapse after prostatectomy. All patients underwent whole body [68Ga]PSMA I&T PET/CT. PET/CT images were evaluated for presence of local recurrence, lymph node metastases, and distant metastases. Proportions of positive PET/CT results were calculated for six subgroups with increasing prostate specific antigen (PSA) levels (<0.5 ng/mL, 0.5 to <1.0 ng/mL, 1.0 to <2.0 ng/mL, 2.0 to <5.0 ng/mL, 5.0 to <10.0, ≥10.0 ng/mL). Detection rates of [68Ga]PSMA I&T were statistically compared with published detection rates of [68Ga]PSMA HBED-CC using exact Fisher’s test.

Results

Median PSA was 0.81 (range: 0.01 – 128) ng/mL. In 58/83 patients (70 %) at least one [68Ga]PSMA I&T positive lesion was detected. Local recurrent cancer was present in 18 patients (22 %), lymph node metastases in 29 patients (35 %), and distant metastases in 15 patients (18 %). The tumor detection rate was positively correlated with PSA levels, resulting in detection rates of 52 % (<0.5 ng/mL), 55 % (0.5 to <1.0 ng/mL), 70 % (1.0 to <2.0 ng/mL), 93 % (2.0 to <5.0 ng/mL), 100 % (5.0 to <10.0 ng/mL), and 100 % (≥10.0 ng/mL). There was no significant difference between the detection rate of [68Ga]PSMA I&T and published detection rates of [68Ga]PSMA HBED-CC (all p>0.05).

Conclusions

[68Ga]PSMA I&T PET/CT has high detection rates of recurrent prostate cancer that are comparable to [68Ga]PSMA HBED-CC.

Keywords

Prostate cancer PET/CT Positron emission tomography PSMA 68Ga 

Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Christoph Berliner
    • 1
  • Milena Tienken
    • 1
  • Thorsten Frenzel
    • 2
  • Yuske Kobayashi
    • 1
  • Annabelle Helberg
    • 1
  • Uve Kirchner
    • 1
  • Susanne Klutmann
    • 1
  • Dirk Beyersdorff
    • 1
    • 3
  • Lars Budäus
    • 3
  • Hans-Jürgen Wester
    • 4
  • Janos Mester
    • 1
  • Peter Bannas
    • 1
  1. 1.Diagnostic and Interventional Radiology and Nuclear MedicineUniversity Medical Center Hamburg-EppendorfHamburgGermany
  2. 2.Ambulatory Center, Department for Radiation OncologyUniversity Medical Center Hamburg-EppendorfHamburgGermany
  3. 3.Martini-KlinikUniversity Medical Center Hamburg-EppendorfHamburgGermany
  4. 4.Pharmaceutical RadiochemistryTechnical University MunichGarchingGermany

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