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Study on the interaction between three benzimidazole anthelmintics and eosin Y by high performance liquid chromatography associating with resonance light scattering and its application

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Abstract

A novel, highly selective, and sensitive resonance light scattering (RLS) detection approach coupled with high performance liquid chromatography (HPLC) was researched and developed for the synchronous analysis of three kinds of benzimidazole anthelmintics, including mebendazole (MBZ), albendazole (ABZ), and fenbendazole (FBZ) for the first time. In the pH range of 3.5–3.7 Britton-Robinson buffer medium, three kinds of anthelmintics, which were separated by HPLC, reacted with eosin Y (EY) to form 1:1 ion-association complexes, resulting in significantly enhanced RLS signals and the maximum peak located at 335 nm. The enhanced RLS intensity was in proportion to the MBZ, ABZ, and FBZ concentration in the range 0.2–25, 0.2–23, and 0.15–20 μg/mL, respectively. The limit of detection was in the range of 0.064–0.16 μg/mL. In addition, human urine was determined to validate the proposed method by spiked samples and real urine samples. Satisfactory results were obtained by HPLC-RLS method.

The diagram mechanism of generating resonance between emitted light and scattered light

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Acknowledgments

This project was supported by the National Natural Science Foundation of China (no. 21277110).

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Authors and Affiliations

  1. School of Chemistry and Chemical Engineering, Southwest University, No.2 Tiansheng Road, Beibei District, Chongqing, 400715, People’s Republic of China

    Ziyu Pan, Jingdong Peng, Xu Zang, Gang Lei, Yan He & Di Liu

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  1. Ziyu Pan
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  2. Jingdong Peng
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  3. Xu Zang
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  4. Gang Lei
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  5. Yan He
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  6. Di Liu
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Correspondence to Jingdong Peng.

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The studies have been approved by the appropriate ethics committee and have been performed in accordance with the ethical standards

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Pan, Z., Peng, J., Zang, X. et al. Study on the interaction between three benzimidazole anthelmintics and eosin Y by high performance liquid chromatography associating with resonance light scattering and its application. Anal Bioanal Chem 408, 5247–5259 (2016). https://doi.org/10.1007/s00216-016-9619-4

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  • DOI: https://doi.org/10.1007/s00216-016-9619-4

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